研究目的
To understand the relationship of the real-time thermal imaging to the thermal damage estimate in an effort to provide a practical and useful interpretation of intraoperative MRT thermal data that may better inform intraoperative decision making.
研究成果
During LITT therapy, the MRT heat map produced alongside the system-generated TDE can be a useful tool for anticipating what the TDE will look like with respect to the real-time thermal imaging. At standard factory settings, the TDE and the area produced within the periphery of the green area are similar in magnitude. As such, the light blue portion of the MRT heat map may serve as an additional means of predicting when critical structures may be at risk during laser ablation if exposed to further thermal stress.
研究不足
The primary limitation concerns the fact that the measurements of the TDE and MRT heat map were taken at a single time point at the very end of the ablation. A second limitation is that these findings rely strongly on the accuracy of the TDE produced by the system-generated software. A final limitation is the lack of stratification by pathology.
1：Experimental Design and Method Selection:
The study retrospectively reviewed 56 patients who underwent MRgLITT for various intracranial procedures. Inclusion criteria required single-laser catheter use, available TDE and MRT data, and MRT temperature map settings with specific parameters.
2：Sample Selection and Data Sources:
Patients were from a single institution and operated on by a single surgeon. All patients underwent the procedure as part of the routine clinical care algorithm at the institution.
3：List of Experimental Equipment and Materials:
The Visualase MRI-Guided Laser Ablation System was used for all ablations. MRT heat-map and TDE were quantified using MATLAB version R2014a.
4：4a. Experimental Procedures and Operational Workflow:
4. Experimental Procedures and Operational Workflow: The procedure was performed under the guidance of MRT, which allows for intraoperative monitoring of the ablation boundaries in real time. The system workstation provided the operator with information via two dynamic images: one displaying the MRT data produced in the form of a heat map, and the other displaying the real-time software-generated thermal damage estimate (TDE).
5：Data Analysis Methods:
Imaging areas were quantified using MATLAB version R2014a. A student’s t-test analysis was used to detect differences between TDE, HM63.9, and HM50.4.
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