研究目的
To develop an implantable, biocompatible, and miniaturized IOP sensor using 2-D plasmonic grating for in situ and in vivo measurement of IOP in various locations within the vitreous and to facilitate measurement of accommodative IOP spikes at the ONH.
研究成果
The article reports a biocompatible and flexible optical sensor based on 2-D gratings that can correlate minor changes in pressure to changes in observed color of reflected light. Future work includes sensor optimization and implantation in a primate model to study glaucoma pathophysiology.
研究不足
The study mentions the need for future work on integrating micro needles on the back of the sensor, developing surgical procedures for sensor fixation and removal, and optimizing the sensor's sensitivity and calibration routines for highly accurate correlation between IOP and visible color.
1:Experimental Design and Method Selection:
The sensor comprises an array of 2-D gratings embedded in a 50-μm-thick polydimethylsiloxane (PDMS) membrane suspended over an air cavity chamber. The structural color from surface plasmon resonance of the metallic 2-D gratings provides IOP information.
2:Sample Selection and Data Sources:
The sensor was tested under a fundus photography setup, mimicking the conditions for implantation near the ONH region.
3:List of Experimental Equipment and Materials:
Includes a microscope lamp, a 20× objective lens, a syringe for pressure adjustment, and a pressure gauge.
4:Experimental Procedures and Operational Workflow:
The sensor was illuminated under normal incidence, and the reflected light was collected for RGB image analysis to detect color changes corresponding to pressure changes.
5:Data Analysis Methods:
RGB image analysis of the segmented images of the sensor was conducted to quantify the change in reflected color with pressure.
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