研究目的
To design and synthesize a novel NIR-II absorbing organic semiconducting polymer amphiphile (OSPA) for enhancing the structural stability of OSPNs and enabling efficient NIR-II light-triggered phototheranostics toward tumor.
研究成果
The OSPA demonstrates high structural stability, excellent photothermal properties, and biocompatibility, making it a promising candidate for NIR-II light-triggered PA imaging and PTT. The amphiphilic design of OSPA effectively avoids aggregation issues, facilitating its accumulation in tumor regions for efficient phototheranostics.
研究不足
The study focuses on the NIR-II window for phototheranostics, which may limit comparison with other wavelengths. The biodistribution and long-term toxicity of OSPA in vivo require further investigation.
1：Experimental Design and Method Selection:
The OSPA was synthesized via Pd (II)-catalyzed Stille coupling reaction, followed by nucleophilic substitution and Cu-catalyzed 'click' reaction to attach PEG side chains.
2：Sample Selection and Data Sources:
4T1 cancer cells and nude mice were used for in vitro and in vivo studies, respectively.
3：List of Experimental Equipment and Materials:
Bruker Ultra Shield Plus NMR instrument, JEOL JEM-2100 transmission electron microscope, DelsaMax Pro particle sizing instrument, Shimadzu UV-3600 UV-vis-NIR spectrophotometer, PowerWave XS/XS2 microplate spectrophotometer.
4：Experimental Procedures and Operational Workflow:
The OSPA was characterized for its optical properties, photothermal effect, and cytotoxicity. In vivo studies included PA imaging and PTT in tumor-bearing mice.
5：Data Analysis Methods:
PA signals and photothermal effects were quantified and correlated with OSPA concentration and irradiation time.
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