研究目的
To develop wireless, wearable phototherapeutic devices with red light-emitting diodes for continuous treatments of ophthalmologic diseases.
研究成果
The study successfully demonstrated the fabrication of wireless, wearable phototherapeutic devices with red light-emitting diodes for continuous ophthalmologic treatments. The devices showed potential effectiveness in reducing cell death caused by oxidative stress and reliable operation in vivo.
研究不足
The study does not address long-term effects of continuous light therapy on the eye or potential discomfort from wearing the devices for extended periods.
1：Experimental Design and Method Selection:
The study involved the fabrication of transparent or miniaturized red light-emitting diodes (LEDs) conformal to the surfaces of glasses and contact lenses. The devices were designed to be wireless and wearable, with control over light intensity.
2：Sample Selection and Data Sources:
Human retinal pigment epithelial (RPE) cells and a live rabbit were used for in-vitro and in-vivo tests, respectively.
3：List of Experimental Equipment and Materials:
Silver nanowire (AgNW) solutions, poly(3,4-ethylenedioxythiophene) (PEDOT:PSS), red polymer (Livilux SPR-001, Merck), and poly[(9,9-bis(3'-(N,N-dimethylamino)propyl)-2,7-fluorene)-alt-2,7-(9,9–dioctylfluorene)] (PFN) were used.
4：Experimental Procedures and Operational Workflow:
The devices were fabricated using electrohydrodynamic jet (e-jet) printing and electrospraying techniques. The effectiveness of the devices was tested through LIVE/DEAD assays on RPE cells and wireless operation on a live rabbit.
5：Data Analysis Methods:
The percentage of live cells was measured after treatment with red OLED light, and the temperature of the contact lens-type device was monitored during operation.
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