研究目的
Investigating the effects of incorporating graphene oxide (GO) into pure iron (Fe) via selective laser melting (SLM) on the microstructure, hardness, biodegradation rate, and cytocompatibility of Fe-xGO composites to address the slow degradation rate of pure iron for clinical applications.
研究成果
The SLMed Fe-xGO composites exhibited faster degradation rates than SLMed Fe, with the Fe-0.8 GO composite showing the finest grains, maximum degradation rate, density, and hardness, along with good cytocompatibility. The study demonstrates the potential of SLM for producing Fe-GO composites with enhanced properties for biodegradable implant applications.
研究不足
The study focused on the effects of GO content up to 1.6 wt.% on the properties of Fe-xGO composites. Higher GO contents or other fabrication methods were not explored. The cytocompatibility was tested in vitro, and in vivo studies are needed for comprehensive biocompatibility assessment.
1：Experimental Design and Method Selection:
The study used selective laser melting (SLM) to prepare Fe-xGO composites with varying GO contents. The microstructure, hardness, biodegradation, and cytocompatibility were investigated.
2：Sample Selection and Data Sources:
Pure iron powder and graphene oxide (GO) powder were used to prepare Fe-xGO composites. The microstructures were examined using optical microscopy and SEM equipped with EDS. XRD was used for phase characterization.
3：List of Experimental Equipment and Materials:
SEM, EDS, XRD, microhardness tester, potentiostat for polarization tests, immersion tests in simulated body fluid (SBF), and cytocompatibility tests using MG63 cells.
4：Experimental Procedures and Operational Workflow:
The composites were prepared by SLM, followed by microstructure examination, hardness testing, biodegradation assessment through potentiodynamic polarization and immersion tests, and cytocompatibility evaluation.
5：Data Analysis Methods:
The corrosion rate was calculated from polarization curves and weight loss measurements. Cytocompatibility was assessed through cell viability assays and fluorescence staining.
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pure iron powder
Changsha Tid Metal Materials
Used as the base material for preparing Fe-xGO composites.
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graphene oxide powder
Chengdu Organic Chemicals, Chinese Academy of Sciences
Used as the reinforcement phase in Fe-xGO composites.
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selective laser melting system
Used to prepare Fe-xGO composites.
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scanning electron microscope
Used to examine the microstructures of the composites.
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energy dispersive spectrometer
Used for compositional analysis of the composites.
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X-ray diffraction
Used to characterize the phases in the microstructures.
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microhardness tester
Used to measure the hardness of the composites.
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potentiostat
Used for potentiodynamic polarization tests.
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simulated body fluid
Used for biodegradation assessment through immersion tests.
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MG63 cells
Used for cytocompatibility evaluation.
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