研究目的
To construct a novel multifunctional nanoplatform based on hollow mesoporous carbon (HMC) for triple stimuli response and dual model antitumor therapy via chemo-photothermal synergistic effect.
研究成果
The Dox/HMC-SS-ZnO nanoplatform demonstrated high drug loading capacity, excellent photothermal conversion efficiency, and satisfactory chemo-photothermal synergistic effect in vitro and in vivo. The system showed potential for efficient triple stimuli-responsive drug delivery and dual model chemo-photothermal synergistic antitumor therapy.
研究不足
The study focuses on a specific nanoplatform and its application in antitumor therapy, which may have limitations in terms of generalizability to other types of cancer or therapeutic approaches. The in vivo studies were conducted on a specific mouse model, which may not fully represent human conditions.
1：Experimental Design and Method Selection:
The study involved the construction of a multifunctional nanoplatform using HMC and ZnO QDs for drug delivery and photothermal therapy.
2：Sample Selection and Data Sources:
4T1 cells and multicellular tumor spheroids (MCTSs) were used for in vitro and in vivo studies.
3：List of Experimental Equipment and Materials:
Instruments included TEM, XRD, DSC, FT-IR, UV-Vis spectrophotometry, and CLSM. Materials included HMC, ZnO QDs, Dox, and various chemical reagents.
4：Experimental Procedures and Operational Workflow:
The study involved the preparation of ZnO QDs and HMC, drug loading, in vitro drug release studies, photothermal effect studies, cellular uptake studies, cytotoxicity tests, and in vivo antitumor therapy.
5：Data Analysis Methods:
Data were analyzed using statistical techniques and software tools for UV-Vis spectrophotometry, CLSM, and FCM.
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