1：Experimental Design and Method Selection:

The experiment involves the interaction of few-cycle laser pulses with aerosolized silica nanoparticles to study the dissociative ionization of ethanol and water molecules on the nanoparticle surface. The technique of reaction nanoscopy is employed to spatially resolve the reaction yield.

2：Sample Selection and Data Sources:

Silica nanoparticles with diameters of 110 nm and 300 nm are used. The nanoparticles are prepared by wet chemistry approaches and characterized by transmission electron microscopy and dynamic light scattering.

3：List of Experimental Equipment and Materials:

The setup includes a reaction nanoscope, an amplified Ti:sapphire laser system (Femtopower Compact Pro HR, Spectra Physics), a hollow core fiber for spectral broadening, and detectors for electrons and ions (channeltron and microchannel plates with a delay-line detector).

4：Experimental Procedures and Operational Workflow:

Nanoparticles are aerosolized and focused into the interaction region of the reaction nanoscope. Few-cycle laser pulses interact with the nanoparticles, and the resulting ions and electrons are detected in coincidence.

5：Data Analysis Methods:

The data is analyzed using semi-classical M3C simulations to model the electron and proton dynamics and to reconstruct the reaction yield landscape from the measured proton momentum distributions.