研究目的
To examine the impact of laser peripheral iridotomy (LPI) on corneal endothelial cell density (ECD) in patients with primary angle-closure suspect (PACS), primary angle closure (PAC), or primary angle-closure glaucoma (PACG).
研究成果
No decrease in ECD was found 6 months after LPI in a South Indian population with PACS or with PAC or PACG. Eyes with more severe disease may experience greater endothelial cell loss after LPI than eyes with PACS, but differences were small and likely not clinically meaningful.
研究不足
Relatively short follow-up period and small changes and high variability in ECD measurements may require a larger population and longer follow-up to detect a change in the corneal endothelium.
1：Experimental Design and Method Selection:
Prospective study comparing ECD before and 6 months after LPI.
2：Sample Selection and Data Sources:
Patients 30 years or older diagnosed with PACS, PAC, or PACG in at least 1 eye were recruited from glaucoma clinics.
3：List of Experimental Equipment and Materials:
Noncontact specular microscopy (Topcon SP-3000p), ultrasound pachymetry (PACSCAN 300P), Goldmann applanation tonometry, and neodymium:yttriumealuminumegarnet laser.
4：Experimental Procedures and Operational Workflow:
Standard ophthalmic assessment, LPI performed with neodymium:yttriumealuminumegarnet laser, ECD evaluated before and 6 months after LPI.
5：Data Analysis Methods:
Paired t tests and nested multilevel model with mixed effects.
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