研究目的
To develop a dual sensing platform for the detection of ascorbic acid (AA) and amoxicillin (AMOX) using laser-induced graphene (LIG) technology combined with molecularly-imprinted polymer (MIP) technology, enabling portable and on-site analysis.
研究成果
The developed dual-LIG device demonstrates the versatility of LIG technology combined with MIP for the simultaneous detection of AA and AMOX. It offers a low-cost, flexible, and highly reproducible solution for on-site analysis, with excellent sensitivity and selectivity. The device's architecture can be easily adjusted for various applications, making it a promising tool for environmental, industrial, and health monitoring.
研究不足
The linear range for AA detection could be widened by improving the template removal step to create more cavities for rebinding. The higher concentration range for AA showed increased error values, suggesting the need for analysis in a lower concentration range for better accuracy.
1：Experimental Design and Method Selection
The methodology involved designing a dual working electrode architecture on a polyimide substrate using LIG technology, followed by the assembly of MIP layers for AA and AMOX detection. The AMOX MIP was developed through electropolymerization of eriochrome black T (EBT), while the AA MIP was assembled based on previous literature.
2：Sample Selection and Data Sources
Standard solutions of AA and AMOX were prepared in ultrapure Milli-Q water and environmental water samples from a well were used for testing the device's performance in real samples.
3：List of Experimental Equipment and Materials
Polyimide substrate (Dupont, 0.075 mm thickness), CO2 laser cutting machine (VLS 3.50, Universal laser systems), silver conductive ink (AG-510 silver ink, Conductive Compounds, Inc.), potentiostat/galvanostat (PalmSense4), Raman spectroscope (Thermo Scientific).
4：Experimental Procedures and Operational Workflow
The dual-LIG device was fabricated by engraving the electrode architecture on a polyimide substrate using LIG technology, followed by the assembly of MIP layers for AA and AMOX. The devices were then tested using cyclic voltammetry (CV) and square wave voltammetry (SWV) for electrochemical measurements.
5：Data Analysis Methods
The analytical performance was evaluated by calibration curves obtained from SWV measurements, with the limit of detection (LOD) calculated as X+3σ, where X represents the average value of the SWV blank signals and σ is the standard deviation of SWV blank signal consecutive readings.
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