研究目的
To review the AFM-IR technology, especially for its rapid developments and extensive applications in nanocontainers, focusing on resonance-enhanced AFM-IR and tapping AFM-IR, and to provide detailed explanations of AFM-IR measurements.
研究成果
AFM-IR has become a new technique for chemical analysis and compositional imaging with nanoscale spatial resolution, suitable for materials with high thermal expansion coefficient, such as polymers and biomaterials. It is expected that publications about AFM-IR will increase significantly in the coming years.
研究不足
Materials with low expansion coefficient, such as inorganic materials, may be better analyzed by other techniques. The collection of full IR spectra has not yet been achieved.
1：Experimental Design and Method Selection:
The chapter reviews the AFM-IR technology, focusing on its developments and applications in studying nanocontainers. It highlights resonance-enhanced AFM-IR and tapping AFM-IR, providing detailed explanations of AFM-IR measurements.
2：Sample Selection and Data Sources:
The study involves a variety of nanocontainers including coatings, polymer blends, drug-loading lipid-polymer membranes, MOFs, and lipid or polymer vesicles.
3：List of Experimental Equipment and Materials:
AFM-IR setup consists of a pulsed wavelength-tunable IR source and an AFM tip. The illumination can be in a bottom-up or top-down configuration.
4：Experimental Procedures and Operational Workflow:
The AFM-IR technique measures thermal expansion of the sample resulting from the absorption of laser pulses, providing chemical images at selected wavelengths or spectra at selected positions.
5：Data Analysis Methods:
The amplitude of the AFM cantilever oscillation is measured for each wavelength as the laser source is tuned to one wavelength at a time, allowing the collection of local IR spectra over a user-selectable range.
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