研究目的
To study how the time-dependent IONP power dissipation can be used to optimize hyperthermia by increasing energy density in tumors while decreasing energy density in surrounding healthy tissue.
研究成果
The maximum power dissipation of IONPs plays a pivotal role in hyperthermia selectivity. Increasing the maximum IONP power dissipation creates a sharper temperature gradient between cancerous and healthy tissues. When planning the time-scheme of hyperthermia treatments, Pmax should be placed toward the end of the treatment. Increasing the time of Pmax being applied to the system increases localization of energy, but the value of Pmax is more important than its duration.
研究不足
Not explicitly mentioned in the provided text.
1：Experimental Design and Method Selection:
A finite element method was developed to solve the Penne’s bioheat transfer equation in the rectangular coordinate system, considering the finite size and spatial location of each individual nanoparticle.
2：Sample Selection and Data Sources:
The simulation space was dictated by a Gaussian probability function, with the center of the Gaussian at the center of the tumor, modeling general diffusion from direct injection of IONPs into the center of the tumor.
3：List of Experimental Equipment and Materials:
Not explicitly mentioned.
4：Experimental Procedures and Operational Workflow:
The Crank–Nicolson scheme was used to solve the equation with 6400 elements providing a sufficiently fine mesh grid. Each IONP was placed onto the simulation space and weighted into the heating function of the element the IONP resides in.
5：Data Analysis Methods:
The temperature gradient was used as the characterizing parameter of hyperthermia selectivity.
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