摘要： Ciprofloxacin and ciprofloxacin-resistant bacteria are emerging concerns that threaten public health due to the heavy use of antibiotics and the development of bacterial resistance in water environments. In this study, we examined an energy-efficient treatment driven by a UV-LED/chlorine reaction with UV-LED chip emitting UV275 nm to remove ciprofloxacin and ciprofloxacin-resistant bacteria in water. Ciprofloxacin degradation during the UV-LED/chlorine reaction followed pseudo-first-order kinetics, and the excessive chlorine dosage has a negative effect on ciprofloxacin removal. Alkaline pH showed the best efficiency for ciprofloxacin removal, and the reactive chlorine species (RCS) played a major role at alkaline pH values. The cleavages of piperazine, cyclopropyl, and quinolone moieties are considered as the principal degradation reactions in the UV-LED/chlorine reaction. Seven byproducts (m/z = 362.9262, 306.1246, 289.0995, 288.1504, 263.0825, 147.0657, and 1183.9977), two chlorinated compounds (chloroform and chlorate) and two anions (formate and nitrate ions) were observed as the identified byproducts. Toxicity of tentatively identified byproducts were estimated by using quantitative structure activity relationship (QSAR). The complete detoxification of D. magna was achieved when applying UV-LED/chlorine process into hospital wastewater containing CIP. The UV-LED/chlorine process showed the best disinfection ability of E. faecium compared to UV-LED photolysis, chlorination, and UV-LED/H2O2 reactions. A significantly lower EE/O value (6.63 × 10-2 kWh/m3/order) during the UV-LED/chlorine reaction was also observed. Our results indicate that the UV-LED/chlorine process can effectively degrade ciprofloxacin and inactivate ciprofloxacin-resistant bacteria.