摘要： Objectives: To present a method for image fusion of cone-beam computed tomography (CBCT)/computed tomography (CT) and magnetic resonance imaging (MRI) and to explore whether the image data sets fused in such a way could aid the detection of temporomandibular joint (TMJ) anatomical structures and lesions. Methods: There were five cases included in this study. One case was space occupying lesion giant cell tumor of tendon sheaths (GCTTS), one case was chronic inflammation in the condyle, one case was articular disc calcification of the bilateral TMJs, and the other two cases were temporomandibular joint disorders (anterior disc displacement without reduction). The digital imaging and communications in medicine (DICOM) format data of CT/CBCT and MRI of the cases were collected, and then imported to the Amira visual software where the registration process was conducted. Based on the different scan model, the registration process could be separated into automatic registration of CT/CBCT with quadrature slice MR images and the semi-automatic registration of CT/CBCT with oblique slice MR images by altering the registration parameters. Rigid transform model and the similarity metric of normalization mutual information (NMI) was used for registration in the present study. Results: The relationship between the soft mass and hard tissue was shown clearly in the fused images when compared to sole observation of CBCT/CT or MR images. The fused images could define the tumor outline and the destructive bone clearly in the same image. The fused results helped the observers to ensure uncertain defects which could not be confirmed only by one image data set. Conclusions: The CT/CBCT and MR images could be fused to aid detection of TMJ anatomical structures and related lesions.