摘要： Dendritic cells (DCs) are one of the most effective antigen presenting cells (APCs), activating na?ve T and B lymphocytes to initiate adaptive immune responses. The engineering of nano-spheres, emulsions or tubules, holds a key for the development of new immunomodulatory agents to either effectively modulate or deliver immunologically active components to target sites. Bovine Serum Albumin capped gold nanoclusters (BSA-AuNCs) are one of the most promising protein based nanoclusters because of their biological compatibility, ultrafine size, large stokes shift, and photoluminescence characteristics. AuNCs stabilized by BSA have recently been investigated for their use as drug carriers and tracking agents for bioimaging and biolabeling. BSA-AuNCs can be delivered to cells with target specificity for therapeutic applications both in vitro and in vivo because of their salient features including biodistribution, targeted binding, high clearance, less toxicity, and well suitability biologically. The present study demonstrated the less cytotoxic response of stable and highly fluorescent BSA-AuNCs in immature dendritic cells and its efficient in vitro labeling with BSA-AuNCs. In this work, we have developed protocols allowing an effective internalization of human monocyte-derived immature dendritic cells with red fluorescent BSA-AuNCs that are less toxic. Results infer that the high uptake efficiency of BSA coated AuNCs is related to their small size and to the nature of the ligand.