摘要： Fe-polyphenols coordination polymers have emerged as a versatile theranostic nanoplatform for biological applications owing to the appealing biocompatibility of precursors from nature. Incorporating bioactive molecules with Fe-polyphenols coordination polymers is greatly significant to take full advantages of their superiorities for advanced application. Herein, we show functional protein-assisted fabrication of Fe-gallic acid (GA) nanonetworks via a mild and facile biomineralization for photothermal therapy. Mild alkaline condition is crucial to obtain protein-Fe-GA nanonetworks with intense near-infrared absorption and their unique network structure allows reducing the leakage to the surrounding normal tissues, benefiting high photothermal therapeutic efficacy and minimal side effects. The proposed bovine serum albumin-Fe-GA nanonetworks are successfully used to eradicate tumor in vivo. In addition, this universal method can be extended to synthesize other protein-involved nanonetworks, such as human serum albumin-Fe-GA and ovalbumin-Fe-GA. More importantly, the intrinsic bioactivity of protein can be retained in the nanonetworks, and the ovalbumin-Fe-GA nanonetworks enable inducing the maturation of immune cells, showing the successful fusion of immune activity of ovalbumin into the nanonetworks. The proposed biomineralization strategy shows a bright prospect in incorporating various functional proteins, such as enzymes and antibodies, to form protein-Fe-GA nanonetworks with good biocompatibility, favorable photothermal effect and specific biological function.