研究目的
This paper investigates the feasibility of using multispectral optoacoustic tomography (MSOT) for 3D temperature imaging, exploiting the temperature dependence of photoacoustic signal amplitudes. It aims to assess the accuracy of this method through numerical simulations and experimental results on agarose phantoms containing gold nanoparticles.
研究成果
The study demonstrates the potential of MSOT for temperature imaging in the context of hyperthermia therapy, with a reconstruction error of about 1.2 oC at 26 oC. The method offers a promising alternative to conventional Grüneisen-parameter-based photoacoustic temperature tomography, with possibilities for further improvement through the use of thermomarkers with highly temperature-sensitive optical absorption spectra and neural network recognition of multiple wavelengths for increased robustness.
研究不足
The main limitations include the influence of wavelength and temperature-dependent shadowing effects on the accuracy of temperature reconstruction, the need for calibration of the temperature dependence of the PA spectrum, and the current experimental temperature range being limited to 25 oC - 37 oC. The method's applicability in clinical settings is also constrained by the variability in tissue composition and the need for encapsulation of thermomarkers to ensure their optical absorption remains insensitive to their biochemical environment.
