摘要： The binding interactions between silica (SiO2), titania (TiO2) or polymeric nanoparticles with hydroxypropyl methacrylate (HPMA) were investigated for enhancing the ultraviolet (UV) detection sensitivity of these nanoparticles in capillary electrophoresis (CE) analysis. HPMA interacted with colloidal SiO2 nanoparticles, producing a larger CE-UV peak at a slightly shorter migration time. An increase in particle size with HPMA binding was validated using dynamic light scattering. The interaction was selective as HPMA did not interact with TiO2 nanoparticles in aqueous suspension. Chitosan coating of SiO2 or TiO2 nanoparticles produced significantly larger hydrodynamic diameters to further enhance the sensitivity of their UV detection. The analytical technique, which involves coating SiO2 nanoparticles with chitosan first and binding with HPMA next, is novel. It has allowed us to achieve a significant enhancement of 50 folds in detection sensitivity.