研究目的
Investigating the method to analyze a partial Mueller matrix for measuring glucose concentration in the presence of scattering.
研究成果
The proposed method successfully measures glucose concentration in the presence of scattering with high sensitivity (20 mg/dl detection limit) and precision (0.004° in optical rotation and 0.0004 in depolarization). This technique is promising for non-invasive continuous glucose monitoring in clinical settings.
研究不足
The method assumes that the depolarizer acts as a uniform depolarizer and that the scattering properties are independent of the polarization state. The technique's sensitivity and accuracy might be affected by the sample's homogeneity and the calibration of the optical components.
1：Experimental Design and Method Selection:
A Mueller matrix polarimeter using dual photoelastic modulators and rotating half wave plates was designed to retrieve four partial Mueller matrices for a particular orientation of half wave plates.
2：Sample Selection and Data Sources:
Different glucose concentrations from the normal to diabetic range (0–400 mg/dl) were prepared with and without scattering (intralipid as a scattering medium).
3：List of Experimental Equipment and Materials:
He-Ne laser, polarizers, photoelastic modulators (PEM1 and PEM2), half wave plates (HWP1 and HWP2), glass cell.
4：Experimental Procedures and Operational Workflow:
The modulated intensity passes through the sample, and the output Stokes vector is analyzed to retrieve the partial Mueller matrix elements.
5：Data Analysis Methods:
Fourier transform of the output modulated intensity was used to retrieve the partial Mueller matrix elements, and trigonometric simplification was applied to calculate optical rotation and depolarization.
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