研究目的
Investigating the domain structure and molecular orientation of paracetamol form II to understand its better water solubility and compressibility compared to form I, using infrared spectroscopy with synchrotron radiation.
研究成果
The study successfully mapped the domain structure and molecular orientation of paracetamol form II using IR spectroscopy. The method allows for the observation of domain boundaries and has potential applications in monitoring phase transitions in real time. The findings contribute to the understanding of paracetamol's physical attributes important for pharmaceutical applications.
研究不足
The study is limited by the resolution of the IR spectroscopy technique and the potential for overestimation of birefringence in thinner regions of the structure. The method requires further exploration to fully reveal its potential.
1：Experimental Design and Method Selection:
Infrared spectroscopy using synchrotron radiation was employed to investigate the domain structure of paracetamol form II. The study focused on absorbance and retardance maps to reveal molecular orientation.
2：Sample Selection and Data Sources:
Paracetamol form II was prepared by melting and quenching paracetamol between CaF2 plates, followed by heating to crystallize into form III and then transforming into form II.
3：List of Experimental Equipment and Materials:
Bruker Vertex 80v spectrometer coupled with a Hyperion 2000 FTIR microscope, liquid nitrogen-cooled narrow-band mercury cadmium telluride (MCT) detector, ZnSe wire-grid polarizer, and synchrotron IR light source.
4：Experimental Procedures and Operational Workflow:
Spectral mapping of transmittance was carried out at different polarization angles to determine absorbance and retardance. The orientation of absorbing species and optical slow/fast-axis were calculated.
5：Data Analysis Methods:
The data were analyzed using fitting functions for transmittance and absorbance to determine molecular orientation and retardance.
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