研究目的
To compare the outcome of the sequence in the two treatments (intravitreal ranibizumab and panretinal photocoagulation) in high-risk proliferative diabetic retinopathy.
研究成果
The IVR+ protocol showed some degree of superiority and may better sustained effect in the PDR treatment in this study. It appeared to be promising in the treatment of high-risk PDR eyes and should be advocated in the future. It remains to be demonstrated if this beneficial effect can be sustained for longer period.
研究不足
The retrospective design made the patients in the two groups not randomized. The number of the subjects in the sample is small. Influencing factors such as the hemoglobin A1c (HbA1c) levels and the status of diabetes were not checked and included in the analyses.
1：Experimental Design and Method Selection:
A retrospective study with a between-group design was conducted to compare the outcomes of two treatment sequences for high-risk proliferative diabetic retinopathy.
2：Sample Selection and Data Sources:
The study included 35 patients with newly diagnosed high-risk proliferative diabetic retinopathy in 43 eyes.
3：List of Experimental Equipment and Materials:
LUCENTIS? (ranibizumab injections; Novartis Pharma Schweiz AG, Risch-Rotkreuz, Switzerland; 0.5 mg) and a 577-nm pattern scan laser photocoagulator (Supra Scan; Quantel Medical, Cournon-d’Auvergne, France) were used.
4：5 mg) and a 577-nm pattern scan laser photocoagulator (Supra Scan; Quantel Medical, Cournon-d’Auvergne, France) were used. Experimental Procedures and Operational Workflow:
4. Experimental Procedures and Operational Workflow: Patients received three intravitreal ranibizumabs interleaved with three panretinal photocoagulations. The first treatment was done 1 week before the second one, with intervals of 4 weeks between intravitreal ranibizumabs and 2 weeks between panretinal photocoagulations.
5：Data Analysis Methods:
The retinal non-perfusion region was measured with fundus fluorescein angiography, and the central macular thickness was measured with optical coherence tomography. Statistical analysis was performed using two-way analysis of variance (ANOVA).
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