研究目的
To investigate the potential of using terahertz radiation for imaging melanomas in frozen skin, focusing on contrast mechanisms based on water content and melanin absorption.
研究成果
The modeling indicates viable contrast for imaging melanomas in frozen skin, with potential for depth imaging up to 5.0 mm, justifying further experimental studies with ex-vivo samples.
研究不足
The accuracy of the modeling was hampered by limited data on dielectric properties of frozen tissues, particularly frozen melanin, and the need for more accurate measurements in the 0.1 to 1.0 THz band.
1：Experimental Design and Method Selection:
The study used computational modeling with the finite difference time domain (FDTD) method at
2：45 THz to simulate imaging of frozen normal skin and melanoma. Sample Selection and Data Sources:
Models were based on literature data for dielectric properties, with normal skin having 70% free water and melanoma having 85% free water, and melanin concentration set at 80mg cm-
3：List of Experimental Equipment and Materials:
XFdtd software from Remcom Inc. was used for simulations.
4：Experimental Procedures and Operational Workflow:
A planar sensor was used to generate images of electric field changes with a 100 Volt, 2 picosecond excitation sampled at
5：45 THz. Two scenarios were modeled:
one with only water content difference and another with melanin absorption.
6：Data Analysis Methods:
Contrast in dB was calculated from the electric field images to differentiate tissues.
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