研究目的
To report experience with photoactivated chromophore corneal cross-linking (PACK-CXL) for treating patients with infectious keratitis.
研究成果
PACK-CXL appears to be a safe and effective adjunctive treatment for infectious keratitis that does not respond to conventional antibiotic therapy, with improvements in visual acuity and corneal healing observed in most cases.
研究不足
Retrospective study design may introduce bias; small sample size; lack of control group; limited generalizability; measurement of corneal thickness not always possible during active keratitis.
1：Experimental Design and Method Selection:
Retrospective study design using the Dresden protocol for corneal cross-linking in sterile conditions.
2：Sample Selection and Data Sources:
27 eyes of 26 patients with infectious keratitis treated at Helsinki University Hospital between 2009 and
3：Selection criteria included lack of clinical response to antibiotics or severe corneal melts. List of Experimental Equipment and Materials:
20 UVA light source for cross-linking, riboflavin solution, antibiotics (e.g., levofloxacin, tobramycin), amniotic membrane for transplant, slit lamp, anterior segment optical coherence tomography (Casia, Tomey, Japan), soft-bandage contact lens (Polar Lens 75%; Polarlens, Ristiina, Finland), and various medications (e.g., Oculac lubricant drops, Panacod pain medication, FML Liquifilm drops).
4：Experimental Procedures and Operational Workflow:
Patients underwent PACK-CXL procedure after 30 min of UVA exposure, followed by rinsing, antibiotic drop instillation, and application of a soft-bandage contact lens for 3 days. Postoperative medication included levofloxacin drops and lubricants. AMT was performed on the same day for some patients. Follow-up ranged from 1 week to 12 months.
5：Data Analysis Methods:
Analysis of visual acuity, re-epithelization time, culture results, and clinical outcomes using descriptive statistics.
独家科研数据包，助您复现前沿成果，加速创新突破
获取完整内容-
anterior segment optical coherence tomography
Casia
Tomey
To evaluate the corneal defect, infiltrate and anterior chamber.
-
levofloxacin
Oftaquix
Santen
Topical antibiotic medication for treating bacterial infections.
-
tobramycin
Tobrex depot
Alcon
Topical antibiotic medication for treating bacterial infections.
-
soft-bandage contact lens
Polar Lens 75%
Polarlens
Applied after the procedure to protect the cornea and promote healing.
-
lubricant drops
Oculac
Novartis Pharma
Used postoperatively to moisten the eye.
-
pain medication
Panacod
Sanofi-Aventis
Used for pain relief after the procedure.
-
fluorometholone acetate drops
FML Liquifilm
Allergan Inc.
Used to reduce inflammation after re-epithelialization.
-
登录查看剩余5件设备及参数对照表
查看全部
