研究目的
To evaluate the effect of chlorogenic acid supplementation in patients with retinitis pigmentosa.
研究成果
Chlorogenic acid may have a beneficial effect on the peripheral area at the margins of retinal degeneration, and should be considered as an anti-oxidant for the management of retinitis pigmentosa. The increased activity in the peripheral retina may raise the possibility of delaying the progressive decline in visual function in hereditary retinal degeneration.
研究不足
The follow-up period was short to evaluate the effects of nutrition supplementation, and the long-term benefit effect remains to be clarified. In addition, this study enrolled a small number of subjects with no control group, raising the possibility of bias. This study included a heterogeneous study population with various degrees of RP progression, various genetic types, altered proteins, and mutations. Another possible factor is that the diseases of patients included in this study were not very advanced, and the patients had considerably larger residual visual function.
1：Experimental Design and Method Selection:
A prospective, non-comparative, single-arm study was conducted to assess the effects of chlorogenic acid supplementation on visual function in retinitis pigmentosa patients using multifocal electroretinography and other standard ophthalmological tests.
2：Sample Selection and Data Sources:
Eighteen patients diagnosed with retinitis pigmentosa were enrolled, excluding those with severe visual field loss, low visual acuity, recent chlorogenic acid use, or abnormal liver/kidney function.
3：List of Experimental Equipment and Materials:
Equipment included RETIscan System for mERG, Humphrey Field Analyzer II for visual field, Vistech 6500 chart for contrast sensitivity, and standard ERG equipment. Chlorogenic acid supplement at 60 mg/day was used.
4：Experimental Procedures and Operational Workflow:
Baseline measurements of visual acuity, mERG, visual field, ERG, and contrast sensitivity were taken. After 3 months of daily chlorogenic acid supplementation, all measurements were repeated.
5：Data Analysis Methods:
Statistical analysis was performed using IBM SPSS Statistics 21, with Wilcoxon signed-rank test to compare pre- and post-treatment values, considering P < 0.05 as significant.
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