- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
Photocatalytic degradation of pharmaceutical micro-pollutants using ZnO
摘要： This research paper presents the results of an experimental investigation of the degradation of three different contaminants including progesterone (PGS), ibuprofen (IBU), and naproxen (NAP) using ZnO as the photocatalyst and ultraviolet (UV) light as a source for catalysts activation. Two operating parameters, namely, catalyst loading and initial concentration of contaminants, were tested in a batch photocatalytic reactor. To demonstrate the large-scale applications, experiments were also conducted in a submerged membrane photocatalytic reactor. It has proven that ZnO photocatalyst degraded the three contaminants very efficiently under almost all the studied experimental conditions, with efficiency rates of 92.3, 94.5, and 98.7 % for PSG, IBU, and NAP, respectively. The photodegradation kinetics study was performed to calculate the reaction rate constant, which is found to follow pseudo-first order kinetics. The membrane photocatalytic reactor was efficient to remove pollutants and it is observed that the degradation rate increases with increasing the membrane oscillation frequency approaching that of the stirred reactor.
关键词： Photocatalytic degradation,Progesterone,Ibuprofen,Photocatalytic batch reactor,Naproxen,Oscillatory membrane reactor,ZnO
更新于2025-09-23 15:22:29
-
Application of Capillary Zone Electrophoresis Coupled with a Diode Array Detector (CZE-DAD) for Simultaneous Analysis of Ibuprofen and Phenylephrine
摘要： Background: A validated method based on capillary zone electrophoresis coupled with a diode array detector (CZE-DAD) was investigated for analyzing binary mixture of ibuprofen (IBU) and phenylephrine (PHE) in their bulk and combined dosage form. Objective: This binary mixture is a challenging one as IBU is acidic and PHE is alkaline, which may affect their simultaneous analysis using CZE. The literature lacks any CZE report for IBU and PHE simultaneous analysis. Methods: Fused silica capillary (85 cm × 75 μm id) was used, and the electrolyte was a 50 mM borate buffer adjusted to pH 11 with 0.5 M NaOH. Results: The concentration ranges were 5–200 and 5–100 μg/mL for IBU and PHE, respectively, using CZE. High efficiency was achieved (N > 92990). Reasonable migration time (tm) was attained (tm< 8.5 min). Conclusions: Although the results obtained by the proposed CZE method and reported HPLC method were statistically comparable, the proposed method showed lower linearity ranges, higher efficiency, and a more reasonable run time. Highlights: CZE-DAD was used for the analysis of IBU and PHE in bulk and tablets, as no report was found for their determination using CZE. Binary mixture is challenging due to differences in chemical and physical properties. A detailed discussion of electrophoretic parameters optimization is included. Confirmation of peak purity was attained using DAD.
关键词： Capillary zone electrophoresis,phenylephrine,diode array detector,simultaneous analysis,ibuprofen
更新于2025-09-23 15:21:01
-
In-situ fabrication of needle-shaped MIL-53(Fe) with 1T-MoS2 and study on its enhanced photocatalytic mechanism of ibuprofen
摘要： High photocatalytic hole-electron pairs separation efficiency and the wide use of inexpensive and earth-abundant materials as cocatalysts in most semiconductor-based photocatalytic systems are desired for improving the photocatalytic activity and practical application. Herein, we report a facile one-pot solvothermal approach of integrating stable metallic nonmetal materials 1T-MoS2 nanosheets with MIL-53(Fe) to form needle-shaped 1T-MoS2@MIL-53(Fe) (TSMF) composites. Interestingly, the introduction of 1T-MoS2 turns nonspecial-structured MIL-53 (Fe) into needle-like structure and the BET analysis reveals that the optimal TSMF composites possess abundant coexistence of micropores and mesopores with a large surface area of 337 m2g-1, which is about 16 folds higher than that of the pure MOFs. Meanwhile, it is remarkable that the photocatalytic rate of ibuprofen (IBP) by optimal TSMF nanocomposites has improved 7.5 and 9.4 times compared to the pristine MIL-53(Fe) and 1T-MoS2, respectively. The photocatalytic efficiency of TSMF composites enhances due to the emerging micropores, which can provide more adsorption and reaction sites. In addition, the formed compact and uniform interface contact between 1T-MoS2 sheets and MOF may dramatically accelerate the separation of the photo-induced charges, thus enhance the photocatalytic activity. We also study the photocatalytic mechanism combined the corresponding electrochemical testing and the photo-degradation intermediates identified by ion chromatography (IC) and LC-MS-MS, indicating that superoxide radicals (·O2-), hydroxyl radical (·OH) and electrons (e-) are the main active radicals in IBP photocatalysis and decarboxylation and hydroxylation are the main degradation pathways of IBP.
关键词： heterojunction structure,Visible light,MIL-53(Fe),ibuprofen,1T-MoS2
更新于2025-09-11 14:15:04
-
Application of derivative emission fluorescence spectroscopy for determination of ibuprofen and phenylephrine simultaneously in tablets and biological fluids
摘要： Two sensitive, rapid, and accurate derivative emission spectrofluorimetric methods applying zero crossing techniques were developed for simultaneous determination of binary mixtures of ibuprofen (IBU) and phenylephrine hydrochloride (PHE) in pure powder, synthetic mixture and combined tablets. The proposed methods were performed via measuring the intersected drug derivative amplitude of one drug at the zero crossing points for the other one and vice versa. The two methods rely on the measurement of the combined drugs native fluorescence after excitation at 270 nm in methanol directly, followed by differentiation using first (D1) and second derivative (D2) techniques. Applying the D1, IBU was measured quantitatively at 293.1 nm at zero crossing of PHE, on the other side; PHE was measured quantitatively at 300.7 nm at zero crossing of IBU. By the same way, applying the D2, the wavelengths selected were 303.5 nm for IBU and 312.9 nm for PHE. The concentration plots of derivative fluorescence intensity were rectilinear over the range of 0.5- 10 μg/mL and 0.025- 0.5 μg/mL for IBU and PHE, respectively. The results obtained with average % recoveries ± RSD are 99.73 ± 0.72 (IBU, D1), 99.49 ± 0.95 (PHE, D1), 99.79 ± 0.47 (IBU, D2), and 99.88 ± 0.34 (PHE, D2) were in good agreement with the comparison method. The proposed methods offer high sensitivity that enable direct analysis of IBU and PHE in spiked human plasma. The proposed methods were entirely validated in terms of ICH guidelines.
关键词： phenylephrine (PHE),ibuprofen (IBU),spiked plasma,derivative emission,Spectrofluorimetry,tablets
更新于2025-09-11 14:15:04
-
Highly efficient solar light-assisted TiO2 nanocrystalline for photodegradation of ibuprofen drug
摘要： Pure anatase, pure brookite, and anatase/brookite heterojunction (ABH) TiO2 with tunable anatase/brookite ratios were prepared via a facile hydrothermal process using Titanium (III) sulfate, as precursor and different glycine/NaOH ratios, as pH adjusting reagents. The obtained samples were characterized by XRD, Raman, FT-IR, FE-SEM, TEM, EDX, BET surface area, UV-vis-DRS, XPS, and PL. The photocatalytic performance of as-synthesized catalysts was evaluated by photodegradation of ibuprofen under simulated solar light. The photodegradation rate of A/B heterojunction TiO2 photocatalysts was greater 12.5, 8.5 and 1.6 times than that the pure brookite, pure anatase, and the commercial P-25, respectively. The complete ibuprofen mineralization (100%) was performed under simulated solar light within 5 h using the photocatalyst obtained at pH 10 (i.e. 1:3 glycine/NaOH volume ratio), however, the commercial P-25 is 75%. The optimum sample containing 61.8%A/38.2%B exhibits the best photocatalytic activity due to it has a mesoporous structure, high surface area, and the low PL intensity.
关键词： Ibuprofen,Solar light,Photodegradation,Anatase-brookiteTiO2,Photocatalyst
更新于2025-09-10 09:29:36
-
Electrochemical properties of the scheelite BaWO4 prepared by co-precipitation: Application to electro-photocatalysis of ibuprofen degradation
摘要： The scheelite BaWO4 elaborated by co-precipitation, is a wide band gap semiconductor crystallizing in the tetragonal symmetry. The oxide is identi?ed by X-ray di?raction and characterized by scanning electron microscopy and di?use re?ectance. The optical transition (2.95 eV) involves O2-: 2p orbital and W6+ eg: level, further direct transition occurs at 4.88 eV. The peaks in the Raman spectrum are assigned to symmetrical vibrations of tetragonal units [WO4]2-. The oxide shows an oxygen de?ciency and the conductivity follows a thermally activated hopping of lattice polaron with activation energy of 0.31 eV. The photo electrochemical analysis of BaWO4 at pH 5.5 gives a ?at band potential of 0.20 VSCE and electrons density of 1.8 × 1019 cm?3. The positive slope of the plot (capacitance?2 - potential) indicates n type conduction, a result con?rmed by chrono-amperometry. The frequency dispersion of the real/imaginary impedances is undertaken both in the dark and under illumination; the response is modeled by an equivalent circuit with a predominant bulk contribution. As application, the photo electrons in the conduction band (?0.11 VSCE) reduce oxygen into radicals O2?, allowing a partial mineralization of ibuprofen, one of the most consumed medicaments. The electro-photocatalysis i.e. combined electrocatalysis/electro-photocatalysis using TiPt as cathode and BaWO4 as anode (100 mA/25 V) shows a high conversion yield (75%), in aerated ibuprofen solution (20 ppm) in less than 6 h under UV light (12 mW cm?2). The reaction follows a pseudo-?rst order kinetic with a rate constant of 3.7 × 10?3 min?1, about twice higher than that obtained by electrocatalysis (50%, k = 1.9 × 10?3 min?1).
关键词： Electro-photocatalysis,Photo electrochemical,Scheelite BaWO4,UV light,Ibuprofen
更新于2025-09-09 09:28:46