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Luminescent Mesoporous Silica Nanohybrid Based on Drug Derivative Terbium Complex
摘要： Mesoporous silica nanoparticles prepared by organic template-driven synthesis have been successfully explored as carriers of the drug-derivate green luminescent complex of terbium (III) with the nonsteroidal anti-inflammatory drug ketoprofen. The terbium (III) complex was synthesized by reacting ketoprofen sodium salt with terbium (III) chloride, which was further adsorbed onto the surface of mesoporous nanoparticles with a mean particle size of 47 ± 4 nm and pore size of 11 nm. The incorporation of the complex into mesoporous silica nanoparticles was tracked by the decrease in the surface area and pore size of the nanoparticles, and successfully demonstrated by substantial changes in the adsorption isotherms and thermal and vibrational spectroscopy results. The cytotoxicity assay and confocal microscopy have shown that the novel luminescent nanohybrid presents high cell viability and the characteristic terbium (III) emission can be assessed through two-photon excitation, which paves the way for bioimaging applications in nanomedicine.
关键词： ketoprofen,mesoporous silica nanoparticles,terbium,luminescent nanohybrid,two-photon
更新于2025-11-21 11:08:12
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In Situ Synthesis of Fluorescent Mesoporous Silica–Carbon Dot Nanohybrids Featuring Folate Receptor-Overexpressing Cancer Cell Targeting and Drug Delivery
摘要： Multifunctional nanocarrier-based theranostics is supposed to overcome some key problems in cancer treatment. In this work, a novel method for the preparation of a fluorescent mesoporous silica–carbon dot nanohybrid was developed. Carbon dots (CDs), from folic acid as the raw material, were prepared in situ and anchored on the surface of amino-modified mesoporous silica nanoparticles (MSNs–NH2) via a microwave-assisted solvothermal reaction. The as-prepared nanohybrid (designated MSNs–CDs) not only exhibited strong and stable yellow emission but also preserved the unique features of MSNs (e.g., mesoporous structure, large specific surface area, and good biocompatibility), demonstrating a potential capability for fluorescence imaging-guided drug delivery. More interestingly, the MSNs–CDs nanohybrid was able to selectively target folate receptor-overexpressing cancer cells (e.g., HeLa), indicating that folic acid still retained its function even after undergoing the solvothermal reaction. Benefited by these excellent properties, the fluorescent MSNs–CDs nanohybrid can be employed as a fluorescence-guided nanocarrier for the targeted delivery of anticancer drugs (e.g., doxorubicin), thereby enhancing chemotherapeutic efficacy and reducing side effects. Our studies may provide a facile strategy for the fabrication of multifunctional MSN-based theranostic platforms, which is beneficial in the diagnosis and therapy of cancers in future.
关键词： Targeted drug delivery,Fluorescence imaging,Mesoporous silica nanoparticles,Carbon dots,Chemotherapy
更新于2025-11-14 14:48:53
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Mesoporous silica-coated gold nanoframes as drug delivery system for remotely controllable chemo-photothermal combination therapy
摘要： Tumor cells experience higher chemotherapy stress under condition of elevated temperature. As a result, developing novel nanoagents that integrates chemotherapy and thermotherapy holds great promise in biomedicine. Herein, utilizing spatially confined galvanic replacement method, we fabricated a yolk-shell Au@mSiO2 nanoframes with Au NPs and mesoporous silica as yolk and shell, respectively, to sever as an excellent drug nanocarrier with effective photothermal conversion efficiency. Taking full advantage of the high temperature response of the Au@mSiO2 nanoframes, the phase change material 1-tetradecanol (TD) was creatively employed as gatekeepers, intelligently controlling the release of loaded agents. Then, the actively targeted Alanine-Alanine-Asparagine, legumain-recognizable oligopeptides was decorated on the surface of the prepared nanoframes. Upon exposure to near-infrared light, the GC-PtAu@mSiO2-TD nanoframes not only exhibited a high localized temperature response, but also triggered the quick release of loaded cargos, and thus improved the chemotherapeutic efficacy. The in vitro cytotoxicity studies indicated the remarkable synergistic effects. Meanwhile, the laser confocal studies and flow cytometry showed the oligopeptides facilitated the intracellular uptake of GC-PtAu@mSiO2-TD nanoframes in MGC-803 cells. Our study highlighted the great potential of the GC-PtAu@mSiO2-TD nanoframes in drug delivery and the combination of chemotherapy and photothermal therapy.
关键词： Cisplatin,Mesoporous silica-gold nanoframes,Phase-change materials,Photothermal therapy,Controlled release
更新于2025-09-23 15:23:52
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Miniaturized electrochemiluminescent biochip prepared on gold nanoparticles-loaded mesoporous silica film for visual detection of hydrogen peroxide released from living cells
摘要： Au nanoparticles (NPs) has been widely used for the detection of intracellular H2O2 to enhance the electron transfer process. But AuNPs are easy to aggregate in the live cells environment. Herein we report a rapid, reliable and low-cost electrochemiluminescent (ECL) biochip integrated by AuNPs-loaded mesoporous silica film (MSF) to detect H2O2 released by macrophage cells. The MSF was employed as a template to load AuNPs within the nanochannels to avoid aggregation. H2O2 could be catalyzed by AuNPs to promote the ECL reaction of luminol molecules in solution. The ECL intensity was significantly enhanced, and the peak potential was negatively shifted by 400 mV due to the excellent electrocatalytic ability of AuNPs. The integrated biochip demonstrated good reproducibility, with a wide linear range of 0.1–200 μM and an LOD of 25.3 nM. The reliability was evaluated by applying for the assessment of antioxidant activity of resveratrol using RAW 264.7 macrophage model. The AuNPs-loaded MSF integrated biochip can be easily adapted to the development of improved devices in biosensing, lab-on-a-chip, and nanofluidic systems.
关键词： Gold nanoparticles,Biochip array,Electrochemiluminescence,Reactive oxygen species,Mesoporous silica
更新于2025-09-23 15:23:52
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Polydopamine-Coated Gold Core/Hollow Mesoporous Silica Shell Particles as a Nanoplatform for Multimode Imaging and Photothermal Therapy of Tumors
摘要： It is highly desirable to develop a new hybrid nanoplatform that integrates diagnosis and treatment elements for effective theranostics of tumors. Herein, we have skillfully designed a nanoplatform of polydopamine (PDA)-coated and perfluorohexane (PFH)-filled gold core/hollow mesoporous silica shell (Au@mSiO2-PFH-PDA, ASPP for short) particles for photoacoustic (PA)/ultrasound (US)/computed tomography (CT)/thermal imaging and photothermal therapy (PTT) of tumors. In this work, we first synthesized Au seed particles with a diameter of 15.8 nm using a sodium citrate reduction method, and coated Au seeds with polyvinylpyrrolidone for further growth of solid silica shell/mesoporous silica shell onto the Au seeds. After treatment via selective etching to remove solid silica shell, amination of surface of the particles, and filling of PFH into the internal cavity of the spheres with a diameter of 182.1 nm, PDA coating was performed to render the particles with an external shell thickness of 15.1 nm. The formed hybrid particles with a size of 212.2 nm are colloidally stable and exhibit good cytocompatibility, and display excellent PA/US/CT/thermal imaging property due to the co-presence of PDA, PFH, and Au nanoparticles. Furthermore, the PDA coating renders the platform with a photothermal conversion efficiency of 61.2%, enabling effective photothermal ablation of cancer cells in vitro and a xenografted 4T1 tumor model in vivo under irradiation with an 808 nm laser. More importantly, in the primary 4T1 tumor model, intratumoral injection of the ASPP and irradiation with an 808 nm laser can also completely inhibit the occurrence lung metastasis induced by the 4T1 tumor. The as-prepared hybrid nanoplatform may hold a great promise to be adopted for multimode imaging and PTT of tumors and inhibition of tumor metastasis.
关键词： Tumor metastasis inhibition,Multimode imaging,Photothermal therapy,Polydopamine NPs,Hollow mesoporous silica,Surface modification
更新于2025-09-23 15:22:29
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GNRs/PPy/m-SiO2 Core/Shell Hybrids as Drug Nanocarriers for Efficient Chemo-Photothermal Therapy
摘要： Combination therapy as a novel strategy with the combination of photothermal therapy and chemotherapy (photothermal-chemotherapy) has aroused the tremendously increasing interest owing to the synergistic therapeutic effect on destroying cancer cells since that the hyperthermia generated from photothermal therapy can promote drug delivery into tumors, which would highly increase therapeutic efficacy as compared to those sole treatments. Herein, we fabricated a novel nanomaterial-based carrier composed of GNRs, polypyrrole (PPy) and mesoporous silica to form GNRs/PPy/m-SiO2 core/shell hybrids. After loading the anticancer drug of doxorubicin (DOX), the photothermal effect and the drug-release behavior of GNRs/PPy@m-SiO2-DOX hybrids were investigated. The in vitro and in vivo near-infrared (NIR) photothermal-chemotherapy were also revealed. The results indicated the NIR-induced photothermal effect was beneficial to promote the release of the drug. In addition, combination therapy demonstrated the enhanced synergistic efficacy and excellent treatment efficacy for cancer therapy.
关键词： drug-controlled release,gold nanorod,mesoporous silica,combination therapy,photothermal,conducting polymer
更新于2025-09-23 15:21:21
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Tunable Chromaticity and High Color Rendering Index of WLEDs with CaAlSiN <sub/>3</sub> :Eu <sup>2+</sup> and YAG:Ce <sup>3+</sup> Dual Phosphora??ina??silicaa??glass
摘要： Phosphors-in-glass (PiG), which serves as a potential bi-replacement of both phosphors and organic encapsulants in high-power white light-emitting diodes (WLEDs), has captured much attention due to its high thermal stability and excellent luminescent properties. However, due to the high temperature-sensitivity and the chemical reactions between phosphors with glass matrix, a variety of phosphors, especially red phosphors could be hardly dispersed into the glass without thermal quenching and decomposition, which greatly limits the improvement of color rendering index and chromaticity tunability of the WLEDs. In this study, adopting the mesoporous silica (FDU-12) and commercial phosphors as raw materials, the phosphors-in-silica-glasses (PiSGs) embedded with red phosphor CaAlSiN3:Eu2+ and yellow phosphor YAG:Ce3+ have been successfully prepared at low sintering temperature (950 ?C) and short preparation time (10 min) using spark plasma sintering. Owing to the well preservation of the originally emissive properties of the embedded phosphors, the warm WLEDs with tunable chromaticity and exhibited a superior performance with LE of 133 lm/W, CCT of 3970 K and CRI of 81 were fabricated by encapsulating the as-prepared PiSGs on the blue chips. Moreover, the PiSG composite exhibits a high thermal conductivity up to 1.6 W/m·K.
关键词： white light-emitting diodes,phosphor in silica glass,tunable chromaticity,mesoporous silica
更新于2025-09-23 15:21:01
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Optical oxygen sensing by MPA-capped CdTe quantum dots immobilized in mesoporous silica
摘要： A novel nanocomposite luminescent material was prepared by taking advantage of the versatile wet impregnation method for the dispersion of CdTe quantum dots (QDs) into mesoporous silica host matrix and thus providing great interaction between oxygen and QDs, with potential application in an optical oxygen sensor. The optical/spectroscopic properties of the QDs suspended in aqueous media and incorporated in mesoporous silica were evaluated as a function of aging time, temperature variation and oxygen concentration. Luminescence quenching studies were carried out for both QDs suspended in solution and loaded into the silica matrix, in the presence of varying O2 concentration. By Stern-Volmer plot analysis, obtained at different temperatures, it was possible to verify the existence of two types of emission quenching mechanisms for CdTe QDs. After aging for 120 days at room temperature, the QDs in colloidal suspension displayed a small red-shifted emission, which was interpreted as a decreased bandgap energy owing to the increase in the nanocrystal size. In contrast, the emission spectrum of CdTe QDs loaded into the mesoporous SiO2 matrix remained unchanged after aging for the same time at ambient temperature. The presented results will contribute to the discernment of oxygen quenching mechanisms and chemical stability of optical sensors based on CdTe QDs.
关键词： oxygen sensors,mesoporous silica,Quantum Dots,CdTe,wet impregnation,fluorescence quenching
更新于2025-09-23 15:21:01
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Mesoporous multi-silica layer-coated Y2O3:Eu core-shell nanoparticles: Synthesis, luminescent properties and cytotoxicity evaluation
摘要： Mesoporous multi-layered silica-coated luminescent Y2O3:Eu nanoparticles (NPs) were prepared by a urea-based decomposition process, and their surfaces were gradually modified with nanoporous and mesoporous silica layers using modified sol-gel methods. The synthesized luminescent core-shell NPs were characterized thoroughly to investigate their structural, morphological, thermal, optical, photo luminescent properties and their surface chemistry. The morphology of the core NPs were nearly spherical in shape and were nano-sized grains. The observed luminescent efficiency of the mesoporous multi-layered silica-coated luminescent core NPs was gradually reduced because of bond formation between the Y2O3:Eu core and the amorphous silica shell via YeOeSieOH bridges on the surface of the NPs; the bonds suppressed the non-radiative transition pathways. Biocompatibility tests on human breast cancer cells using the 3?(4,5?Dimethylthiazol?2?yl)?2,5?diphenyltetrazolium bromide and lactate dehydrogenase assays indicated that the core-shell NPs were non-toxic even at high concentrations. The mesoporous SiO2 layer played a key role in perfecting the solubility, biocompatibility, and non-toxicity of the NPs. The zeta potential, surface chemistry (Fourier transform infrared spectroscopy), and optical absorption spectral analyses revealed the high hydrophilicity of the as-prepared core-shell NPs because of the active surface-functionalized silanol (SieOH) groups, which could potentially offer many exciting opportunities in photonic-based biomedical applications.
关键词： Cytotoxicity,Mesoporous silica shell,Photoluminescence,Yttrium oxide,Raman spectra,Biocompatibility
更新于2025-09-23 15:21:01
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Two-photon pumped spaser based on the CdS/ZnS core/shell quantum dota??mesoporous silicaa??metal structure
摘要： The spaser (a plasmonic nanolaser) has rapidly advanced as a subwavelength light source candidate. Herein, we introduce a spaser based on a quantum-dot, mesoporous-oxide, and metal structure from top to bottom consisting of CdS/ZnS core/shell quantum dots, a mesoporous silica film (MSF), and an Au film, respectively. Two-photon pumping using femtosecond laser pulses at 800 nm creates amplified spontaneous emission at approximately 451 nm. The advantages of MSF as a dielectric gap layer are examined through numerical simulations. Measuring the dependence of the luminescence intensity on the average pump power confirms the occurrence of two-photon up-conversion luminescence.
关键词： spaser,two-photon pumping,mesoporous silica film,plasmonic nanolaser,quantum dots
更新于2025-09-23 15:19:57