- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
Fluorescent Metal-Doped Carbon Dots for Neuronal Manipulations
摘要： There is a growing need for biocompatible nanocomposites that may efficiently interact with biological tissues through multiple modalities. Carbon dots (CDs) could serve as biocompatible fluorescence nanomaterials for targeted tissue/cell imaging. Important goals toward this end are to enhance the fluorescence quantum yields of the CDs and to increase their targetability to cells. Here, sonochemistry was used to develop a one-pot synthesis of CDs, including metal-doped CDs (M@CDs), demonstrating how various experimental parameters, such as sonication time, temperature, and power of sonication affect the size of the CDs (2–10 nm) and their fluorescence properties. The highest measured quantum yield of emission was ~16%. Similarly, we synthesized CDs doped with different metals (M@CDs) including Ga, Sn, Zn, Ag, and Au. The interaction of M@CDs with neuron-like cells was examined and showed efficient uptake and low cytotoxicity. Moreover, the influence of the M@CDs on the improvement of neurites during initiation and elongation growth phases were compared with pristine CDs. Our research demonstrates the use of M@CDs for imaging and for neuronal interactions. The M@CD nanocomposites are promising due to their biocompatibility, photo-stability and potential selective affinity, paving the way for multifunctional biomedical applications.
关键词： sonication,neurite outgrowth,biocompatibility,metal-doped carbon dots,neural tissue engineering,fluorescence
更新于2025-09-09 09:28:46
-
Nanostructured Titanium Dioxide Based on Titanium Alloys: Synthesis and Properties
摘要： Titanium dioxide (TiO2) has provoked a significant amount of scientific and technological interest due to their anticipated impact in the fields of photocatalysis, solar cells, lithium-ion battery electrodes, and biomedical devices. This is particularly apparent in the case of anodization and ion implantation for modifying Ti-based alloys. However, the lack of sufficient solar light absorption and limited hole diffusion significantly affect the performance of TiO2 in photocatalysis. Moreover, the biocompatibility and corrosion resistance of Ti-based biomedical device need to be enhanced to achieve a longer service life. In the present review, the MOx prepared by anodization is described first. Then, the electrolyte parameters during anodization are assessed by comparing various electrolytes including ethylene glycol, glycerol, formamide, and aqueous electrolytes. Additionally, the effects of ion implantation on the surface of Ti-based alloy are outlined. By analyzing the impact on various synthetic method and modification strategies of nanostructured TiO2, the essential elements of suitable in situ doping ratio and ion implantation dose are addressed. Finally, the outlook for anodization and ion implantation for constructing nanostructured TiO2 is discussed, highlighting challenges and key areas for future research and development.
关键词： Anodization,Water Splitting,Biocompatibility,TiO2-Based Ti Alloy,Ion Implantation
更新于2025-09-09 09:28:46
-
A comprehensive review on thin film-based nano-biosensor for uric acid determination: arthritis diagnosis
摘要： This article aims to provide a survey on the development of thin film-based nano-biosensor over the decade, which includes sensing principles, electrode types and various thin film matrices. The theoretical and experimental results suggest that the thin film-based sensor are suitable for highly sensitive detection of low concentration bio molecules and can be used for early diagnosis and screening of arthritis, kidney diseases and other cardiovascular diseases. This review concludes that enzyme immobilisation and surface functionalisation methods were used to increase sensitivity of the biosensor and new combination of polymer nano-composites with metal oxide thin films results in increased efficiency due to its high biocompatibility.
关键词： nanomaterials,enzymes,thin films,uric acid,immobilisation,biocompatibility
更新于2025-09-09 09:28:46
-
Contact Lenses || Contact Lens Materials
摘要： The chapter provides an overview of contact lens materials, focusing on their development, properties, and the ocular response they elicit. It discusses the evolution from glass and PMMA to silicone hydrogels, highlighting the importance of oxygen permeability, wettability, and mechanical properties in lens design. The chapter also explores the challenges in achieving biocompatibility and comfort, the impact of lens materials on ocular health, and the future directions in materials development to address issues like dry eye and the ageing ocular surface.
关键词： Oxygen Permeability,Dry Eye,Ocular Response,Ageing Anterior Eye,Silicone Hydrogels,Contact Lens Materials,Biocompatibility
更新于2025-09-04 15:30:14
-
Combination of CuS and g-C3N4 QDs on upconversion nanoparticles for targeted photothermal and photodynamic cancer therapy
摘要： Combined therapy with multimodal therapeutic agents based on nanomaterials has been shown as a promising approach to cancer treatment. In this report, a highly efficient multifunctional anti-cancer nanocomposite was fabricated by assembling a photothermal agent (CuS nanoparticles) and a photodynamic agent (g-C3N4 quantum dots) on upconversion nanoparticles (UCNPs) after mesoporous silica coating. Then, the surface modification of the obtained nanocomposite (abbreviated as CUSCs) with polyethylene glycol (PEG) and folic acid (FA) endows the final sample (denoted as CUSCs-PEG-FA) with an excellent cancer cell targeting effect and biocompatibility. In this nanoplatform, CuS nanoparticles are an inorganic substance with low toxicity and high photothermal conversion efficiency. g-C3N4 QDs have excellent biocompatibility and are beneficial for cellular uptake due to their small size. UCNPs can be excited by near-infrared (NIR) light to produce ultraviolet and visible (UV-vis) light emission, which overlaps with the UV absorption peak of high fluorescence g-C3N4 quantum dots (QDs). Therefore, when the nanocomposite is excited by 808 nm NIR light, a synergistic treatment effect will be presented. Since the wavelengths absorbed by the chosen photothermal agent and the photosensitizer are different, sufficient utilization of energy can be achieved. Combining photothermal therapy (high photothermal conversion efficiency of 27.4%) and photodynamic therapy can inhibit cancer more effectively compared to any monotherapy. Moreover, as a result of the inherent performance ability of the doped rare earth ions, excellent applicability for computed tomography (CT), upconversion luminescence (UCL) and magnetic resonance imaging (MRI) has been achieved.
关键词： CuS,Upconversion,g-C3N4,Synergistic treatment,Biocompatibility
更新于2025-09-04 15:30:14
-
Heparin-grafted PVA hydrogels: a material for the optical part of artificial cornea
摘要： Heparin (Hep) was grafted to a poly(vinyl alcohol) (PVA) hydrogel surface by using the covalent grafting method. The structure of the modified hydrogel was determined from Fourier transform infrared attenuated total reflection and X-ray photoelectron spectroscopy. The effects of the concentration of (3-aminopropyl)triethoxysilane (kh550) and Hep on visible light transmittance, moisture content, equilibrium swelling, hydrophilicity and percentage of Hep sodium release of the composite hydrogel were studied. The visible light transmittance of the modified PVA hydrogel was above 94%. The time of swelling equilibrium was about 60 min and the equilibrium swelling ratio ranged from 3·0 to 3·5. The hydrophilicity was enhanced, and the static water contact angle decreased from 41 to 28°. The bioeffects of the PVA–kh550–Hep hydrogel were evaluated by studying cell adhesion and proliferation. During the adhesion assay in vitro, cell adhesion significantly decreased after the interfaces had been modified with Hep. The Cell Counting Kit-8 assay showed that the biocompatibility of the PVA–kh550–Hep hydrogel improved obviously compared to that of pure PVA. The experimental results demonstrated that the PVA–kh550–Hep hydrogel had good stability, bioactivity and biocompatibility, suggesting its potential applications in artificial corneas.
关键词： biocompatibility,surface modification,adhesion
更新于2025-09-04 15:30:14
-
Silicon Carbide Biotechnology || SiC RF Antennas for In Vivo Glucose Monitoring and WiFi Applications
摘要： The American Diabetes Association estimates that nearly 10% of the US population has diabetes and that, by 2050, one in three Americans will have diabetes. Diabetes mellitus is a metabolic disease in which the body is unable to produce or properly use insulin, leading to elevated glucose levels in the blood, known as hyperglycemia. A person with frequent or extended episodes of hyperglycemia can suffer from complications in the nervous system, blood vessels, and other organs, as well as heart disease, kidney disease, strokes, vision loss, and amputation [1,2,3]. Therefore, maintaining a healthy glucose level is essential in a person’s life.
关键词： SiC,Biocompatibility,RF Antennas,Glucose Monitoring,WiFi Applications,Diabetes
更新于2025-09-04 15:30:14
-
Exopolysaccharide-Derived Carbon Dots for Microbial Viability Assessment
摘要： Fluorescent dye staining combined with fluorescence microscopy or flow cytometry is becoming a routine way to monitor microorganism viability that is necessary for food safety, antibiotic development, and human health. However, the conventional live/dead assay dyes suffer from high cost, inconvenient staining steps, and high cytotoxicity, which is urgently needed to overcome. Herein, cheap carbon dots, CDs-EPS605, were reported to successfully assess microbial viability in a convenient way with neglectable cytotoxicity. The fluorescent N-doped CDs-EPS605 could be facilely prepared from bacterial amino exopolysaccharide (EPS) by one-step hydrothermal carbonization, which is cost-effective and sustainable. The negatively charged CDs-EPS605 consisted of C, H, O, N, P, and S, and featured various functional groups, including -COOH, -OH, -CONH-, and -NH2. CDs-EPS605 were observed to sensitively and selectively stain dead microorganisms instead of live ones to enable discrimination of live/dead microorganisms. The labeling method with CDs-EPS605 did not require protection from light, or washing, which is convenient. Additionally, CDs-EPS605 displayed better photostability and much less cytotoxicity compared to the commercial counterpart. Altogether, CDs-EPS605 represent a simple, yet powerful staining agent for microbial viability assessment, and at the same time enrich the current applications of microbial EPS.
关键词： polysaccharides,carbon-based nanomaterial,biocompatibility,photostability,microbial viability assessment
更新于2025-09-04 15:30:14
-
Effect of Surface Coating of Gold Nanoparticles on Cytotoxicity and Cell Cycle Progression
摘要： Gold nanoparticles (GNPs) are usually wrapped with biocompatible polymers in biomedical field, however, the effect of biocompatible polymers of gold nanoparticles on cellular responses are still not fully understood. In this study, GNPs with/without polymer wrapping were used as model probes for the investigation of cytotoxicity and cell cycle progression. Our results show that the bovine serum albumin (BSA) coated GNPs (BSA-GNPs) had been transported into lysosomes after endocytosis. The lysosomal accumulation had then led to increased binding between kinesin 5 and microtubules, enhanced microtubule stabilization, and eventually induced G2/M arrest through the regulation of cadherin 1. In contrast, the bare GNPs experienced lysosomal escape, resulting in microtubule damage and G0/G1 arrest through the regulation of proliferating cell nuclear antigen. Overall, our findings showed that both naked and BSA wrapped gold nanoparticles had cytotoxicity, however, they affected cell proliferation via different pathways. This will greatly help us to regulate cell responses for different biomedical applications.
关键词： surface biocompatibility,microtubule,proteomics,nanoparticle location,cell cycle
更新于2025-09-04 15:30:14