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Changes in Retinal Layer Thickness in the?Contralateral Eye of Patients with Unilateral Neovascular Age-Related Macular Degeneration
摘要： To evaluate the thickness of the outer retinal layers and its relationship with visual function in fellow eyes of participants with unilateral neovascular age-related macular degeneration (AMD). Design: Longitudinal study. Participants: We enrolled 105 subjects with unilateral neovascular AMD from 3 clinical centers in Europe. Methods: The fellow eye, without advanced AMD, was selected for the study. Subjects were followed up with visits occurring every 6 months for 2 years. Spectral domain optical coherence tomography volume scans were collected at 3 clinical sites, in Belfast, Northern Ireland; Coimbra, Portugal; and Milan, Italy. Detailed manual segmentation of outer retinal layers was performed using the custom-designed and validated grading software 3D OCTOR. Thickness measurements for neurosensory retina, photoreceptor layer (PRL) outer segments, retinal pigment epithelium plus drusen (RPEtdrusen) complex, and choroidal layers from each sector of the standard macular grid were obtained. Measures of vison were distance visual acuity, near visual acuity, Smith-Kettlewell Institute low-luminance acuity score, and reading speed. Subjects were grouped based on the presence or absence of subretinal drusenoid deposits (SDDs) for further analysis. Main Outcome Measures: Change in thickness of retinal layers and change in measures of vision. Results: In all, 85 eyes were included in the analysis. The average duration of follow-up was 20.5 (cid:2) 5.8 months. By the ?nal visit, the RPEtdrusen complex was signi?cantly thinner when compared with baseline (29.7 mm vs. 34.09 mm; P ? 0.03). Low-luminance de?cit was signi?cantly worse at the ?nal visit (P < 0.001) and correlated with PRL outer segment thickness (r ? 0.33; P ?0.02). The RPEtdrusen complex was signi?cantly thicker in eyes with SDDs compared with that in those without SDDs (30.67 mm vs. 28.64 mm; P ? 0.02). PRL outer segments became signi?cantly thinner over time in eyes with SDDs compared with those in eyes without SDDs. Conclusions: The RPEtdrusen complex layer becomes thinner over time in fellow eyes of subjects with unilateral neovascular AMD. The rate of PRL outer segment thinning was higher in eyes with SDDs than in eyes without SDDs. These ?ndings are preliminary steps in the identi?cation of early biomarkers for detecting and monitoring the progression of AMD. Ophthalmology Retina 2018;-:1e10 a 2018 Published by Elsevier Inc. on behalf of the American Academy of Ophthalmology
关键词： spectral domain optical coherence tomography,visual function,retinal layer thickness,subretinal drusenoid deposits,age-related macular degeneration
更新于2025-09-23 15:21:01
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Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema
摘要： Purpose. Diabetes is known to cause alterations in retinal microvasculature and tissue that progressively lead to visual impairment. Optical coherence tomography (OCT) is useful for assessment of total retinal thickening due to diabetic macular edema (DME). In the current study, we determined associations between visual acuity (VA) and retinal layer thickness, reflectance, and interface disruption derived from enface OCT images in subjects with and without DME. Materials and Methods. Best corrected VA was measured and high-density OCT volume scans were acquired in 149 diabetic subjects. A previously established image segmentation method identified retinal layer interfaces and locations of visually indiscernible (disrupted) interfaces. Enface thickness maps and reflectance images of the nerve fiber layer (NFL), combined ganglion cell and inner plexiform layer (GCLIPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), photoreceptor outer segment layer (OSL), and retinal pigment epithelium (RPE) were generated in the central macular subfield. The associations among VA and retinal layer metrics were determined by multivariate linear regressions after adjusting for covariates (age, sex, race, HbA1c, diabetes type, and duration) and correcting for multiple comparisons. Results. In DME subjects, increased GCLIPL and OPL thickness and decreased OSL thickness were associated with reduced VA. Furthermore, increased NFL reflectance and decreased OSL reflectance were associated with reduced VA. Additionally, increased areas of INL and ONL interface disruptions were associated with reduced VA. In subjects without DME, increased INL thickness was associated with reduced VA, whereas in subjects without DME but with previous antivascular endothelium growth factor treatment, thickening of OPL was associated with reduced VA. Conclusions. Alterations in retinal layer thickness and reflectance metrics derived from enface OCT images were associated with reduced VA with and without presence of DME, suggestive of their potential for monitoring development, progression, and treatment of DME.
关键词： retinal layer reflectance,visual acuity,retinal layer thickness,optical coherence tomography,diabetic macular edema,interface disruption
更新于2025-09-11 14:15:04
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The Repeatability of Retinal Layer Thickness Measurements with Spectral-Domain Optical Coherence Tomography in Normal Eyes
摘要： Purpose: To evaluate the repeatability of retinal layer thickness measurements in normal eyes imaged using spectral domain optical coherence tomography (SD-OCT). Methods: Sixty-eight eyes of 34 healthy subjects were enrolled in this study. Imaging was performed 4 times using 9 × 9 mm macular scans with SD-OCT (RS 3000 Advance HD OCT, NIDEK, Gamagori, Japan) at the same visit by an experienced examiner. After automatic retinal segmentation (layering) in 5 layers, the thickness of each layer was calculated. Macular thickness of 9 Early Treatment of Diabetic Retinopathy Study (ETDRS)–like regions was obtained. Repeatability for each of the 9 subfield areas was calculated by their repeatability coefficients and intraclass correlation coefficients (ICCs). Results: There was no significant difference in average retinal thickness and each retinal layer thickness between all measurements acquired by the experienced examiner. The ICCs of retinal layer thickness ranged from 0.826 to 0.847 for the ganglion cell layer + inner plexiform layer, inner nuclear layer + outer plexiform layer and outer nuclear layer + external limiting membrane in the fovea. The ICCs were greater than 0.909 for the other intra-retinal layers in all 9 ETDRS subfield thickness between all measurement pairs. Conclusions: Excellent repeatability was observed for SD-OCT retinal segmented layer thickness measurements in healthy subjects.
关键词： Repeatability,Spectral domain optical coherence tomography,Retinal layer thickness,Automated segmentation,Intraclass correlation coefficients
更新于2025-09-10 09:29:36
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Macular Inner Retinal Layer Thickness in Relation to Photopic and Mesopic Contrast Sensitivity in Healthy Young and Older Subjects
摘要： PURPOSE. To examine relationships between the thicknesses of ganglion cell (GC)-related macular layers and central photopic or mesopic contrast sensitivity (CS) in healthy eyes. METHODS. Measurements were made in 38 young and 38 older healthy individuals. Total, inner, layer (IRL) thicknesses were measured in the macula region through and outer retinal spectral-domain optical coherence tomography (SD-OCT) across three sub?elds, or rings, centered at the fovea: central foveal, pericentral, and peripheral. Ganglion cell complex and circumpapillary retinal nerve ?ber layer thicknesses were also measured. Low-spatial-frequency CS for gratings presented at the central 108 visual ?eld were measured through computerized psychophysical tests under photopic and mesopic conditions. Relationships were examined by uni- and multivariate regression analysis. RESULTS. Peripheral IRL thickness emerged as the only independent predictor of photopic CS (P ? 0.001) in the young group and of photopic (P ? 0.026) and mesopic CS (P ? 0.001) in the older group. The slopes of regression lines used to predict CS from peripheral IRL thickness were signi?cantly different for pair-wise comparisons of both photopic CS and age group (P ? 0.0001) and mesopic CS (P ? 0.0001) and age group. These models explained 37% of the variability in photopic CS and 36% of the variability in mesopic CS. CONCLUSIONS. Macular IRL thinning likely due to GC loss was related to reduced photopic and mesopic CS in older healthy eyes. In contrast, in the young eyes, a thicker macular IRL, possibly indicating transient gliosis, was associated with reduced CS.
关键词： contrast sensitivity,optical coherence tomography,retinal ganglion cells,macular inner retinal layer thickness,mesopic vision,glial cells
更新于2025-09-04 15:30:14
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Evaluation of Each Retinal Layer Thickness According to Preoperative OCT Patterns after Idiopathic ERM Removal
摘要： ??: ??? ???????? ? ? ????????? ???? ??? ?? ?? ?? ???? ????? ??? ??? ????, ?????? ????? ????? ???. ??? ??: ??? ?????? ??? ?? 6?? ?? ????? ???? ?? 63? 63?? ???? ????? ?????. ? ? ???????? ?? ????? ??? ???, ???, ????? ???? ?? ?? ???? ????? ??? ??? ????, ?????? ????? ??? ???. ??: ? ? ??? ???, ???, ??? ????, ?????? ??? ????? ???. ???? ?? ? ? ? ??????+????, ????, ?????? ???, ???, ??? ??? ??? ????? ???, ? ? ??????+????? ?????? ???, ???, ??? ??? ????? ??? ??? ???. ? ? ??? ???? ??? ? ? ???? ???, ????? ????? ? ? ??????+????? ?????, ?????? ????? ????? ?? ??? ????. ??: ??? ???????? ????????? ???? ??? ?? ? ? ???? ??? ??? ???. ?? ???? ??? ?? ? ? ??? ???? ?? ? ????? ???? ??? ????? ??? ???? ??? ? ???.
关键词： Epiretinal membrane,Retinal layer thickness,Optical coherence tomography
更新于2025-09-04 15:30:14