研究目的
To learn the effect of TILS on hemodynamics of the human brain from experimental data using longitudinal data analysis methods.
研究成果
The functional mixed-effect model was selected as the best model for analyzing the effect of TILS on hemodynamics, showing that TILS increases the concentration of oxygenated hemoglobin in the brain, with this effect sustaining even after the treatment stops. There is considerable variation among individual responses to TILS.
研究不足
The study is limited by the small sample size of 11 participants, which may not fully reflect the true pattern of the population and individual heterogeneity. Additionally, characteristics of participants such as age, gender, and education level were not collected, which could improve the prediction performance of the proposed methods at the individual level.
1：Experimental Design and Method Selection:
The study uses longitudinal data analysis methods, including repeated measures ANOVA, parametric mixed-effect models, and a non-parametric functional mixed-effect model to analyze the effect of TILS on hemodynamics.
2：Sample Selection and Data Sources:
Data were collected from 11 healthy participants undergoing TILS and placebo treatments, with hemodynamic responses measured using a broadband near-infrared spectroscopy (bb-NIRS) system.
3：List of Experimental Equipment and Materials:
A 1064-nm continuous wave laser device and a single-channel broadband near-infrared spectroscopy (bb-NIRS) system were used.
4：Experimental Procedures and Operational Workflow:
Each experiment lasted 15 minutes, divided into pre-treatment, treatment, and recovery stages, with spectral data collected during laser-off periods.
5：Data Analysis Methods:
The study applied repeated measures ANOVA, parametric mixed-effect models, and a functional mixed-effect model to analyze the data.
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