研究目的
To develop pH-switchable, fluorescent, hybrid, water-dispersible nanomaterials based on boron nitride nanotubes (BNNTs) and grafted copolymer brushes for cellular imaging applications.
研究成果
The developed pH-switchable, fluorescent, hybrid nanomaterials based on BNNTs and grafted copolymer brushes exhibit excellent dispersibility in water, pH-dependent fluorescence properties, and are easily taken up by cells, making them promising for cellular imaging and other biomedical applications.
研究不足
The study focuses on the fabrication and preliminary evaluation of the nanomaterials for cellular imaging, with potential areas for optimization in the functionalization process and further evaluation in biomedical applications.
1：Experimental Design and Method Selection:
A two-step process involving the functionalization of BNNTs with oligoperoxide and subsequent grafting copolymerization of acrylic acid and fluorescein acrylate to fabricate grafted polymer brushes.
2：Sample Selection and Data Sources:
BNNTs synthesized by chemical vapor deposition from colemanite and Fe2O3, purified and modified with oligoperoxide and P(AA-co-FA).
3：List of Experimental Equipment and Materials:
Includes Perkin Elmer Pyris 1 TGA instrument, NICOLET iS50 FTIR spectrometer, Zeiss Axio Imager M2 laser scanning confocal microscope, Lambda 35 UV–vis spectrophotometer, Varian Eclipse spectrophotometer, Zetasizer Nano ZS device, and Carl Zeiss Evo-40 SEM instrument.
4：Experimental Procedures and Operational Workflow:
Detailed synthesis and modification procedures for BNNTs, characterization techniques, and cellular uptake studies.
5：Data Analysis Methods:
Spectroscopic, gravimetric, and imaging techniques for confirming functionalization and evaluating properties.
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Lambda 35 UV–vis spectrophotometer
Lambda 35
PerkinElmer
Ultraviolet–visible spectrometry
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Zetasizer Nano ZS
Nano ZS
Malvern
Dynamic light scattering
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Carl Zeiss Evo-40
Evo-40
Carl Zeiss
Scanning electron microscopy
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Perkin Elmer Pyris 1 TGA
Pyris 1
Perkin Elmer
Thermogravimetric analysis
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NICOLET iS50 FTIR spectrometer
iS50
Thermo Scientific
Fourier transform infrared spectroscopy
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Zeiss Axio Imager M2 laser scanning confocal microscope
Axio Imager M2
Carl Zeiss
Laser scanning confocal microscopy
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Varian Eclipse spectrophotometer
Eclipse
Varian
Fluorescence spectrophotometry
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