研究目的
Investigating the application of hydrophilic, porous, and hollow cobalt/manganese oxide (CMO) nanocrystals (NCs) as photothermal and T1-MR imaging control agents for efficient photothermal therapy of tumors.
研究成果
CMO NCs with a porous and hollow structure have been successfully prepared by a simple hydrothermal route. They exhibit excellent photothermal conversion performance and are effective for MR imaging in vivo. The in vitro and in vivo toxicity results indicate their excellent biocompatibility. CMO NCs can be used as theragnosis nanoplatforms with MR/NIR imaging for efficient photothermal theragnosis therapy.
研究不足
The study focuses on the synthesis and preliminary application of CMO NCs for photothermal therapy and MR imaging. Further studies are needed to optimize the synthesis process, enhance the photothermal conversion efficiency, and evaluate the long-term biocompatibility and toxicity in vivo.
1：Experimental Design and Method Selection:
Hydrophilic porous and hollow CMO NCs were synthesized via a simple hydrothermal method.
2：Sample Selection and Data Sources:
The morphology and size of the NCs were determined by TEM and SEM. UV-Vis-NIR absorbance spectra were obtained to evaluate photothermal performance.
3：List of Experimental Equipment and Materials:
TEM (JEM-2100F, JEOL, Japan), UV-Visible-NIR spectrophotometer (UV-1902PC, Phenix), XRD (Rigaku D/Max-2550 V, Geigerflex), XPS (ESCA-Lab 250Xi), ICP-AES (Leeman Laboratories Prodigy).
4：Experimental Procedures and Operational Workflow:
Synthesis of CMO NCs, characterization, measurement of photothermal effect, in vitro cellular experiment, MR imaging, in vivo photothermal therapy, histological examination.
5：Data Analysis Methods:
Photothermal conversion efficiency was calculated using a modified method similar to that reported by Roper et al. (2007).
独家科研数据包，助您复现前沿成果，加速创新突破
获取完整内容
