研究目的
To evaluate whether stone dust can be obtained from all prevailing stone composition types using the thulium fiber laser (TFL) for lithotripsy and to characterize stone dust by morpho-constitutional analysis.
研究成果
The TFL is capable of disintegration of all prevailing urinary stone composition types into particles considerably smaller than 500 μm. Morpho-constitutional changes found in stone dust suggest a photothermal interaction of laser energy with the stone matrix during TFL lithotripsy.
研究不足
The study was performed in vitro, which may not fully replicate in vivo conditions. The exact definition of stone dust has not been universally agreed upon.
1：Experimental Design and Method Selection:
Human urinary stones were submitted to in vitro lithotripsy using a FiberLase U2 TFL generator with 150 μm silica core fibers. Laser settings were
2：05 J, 320 Hz and 200 μs. A total of 2400 J were delivered to each stone composition type. Sample Selection and Data Sources:
Stones with a volume of approximately 300 mm3 and a > 90% degree of purity were selected.
3：List of Experimental Equipment and Materials:
FiberLase U2 TFL generator, 150 μm silica core fibers, LithoVue flexible ureteroscope, Zeiss Gemini Supra 55VP SEM, Bruker Vector 22 spectrometer.
4：Experimental Procedures and Operational Workflow:
Laser lithotripsy was performed under direct visual control in glass cuvettes filled with saline using a LithoVue flexible ureteroscope with painting movements of the laser fiber tip over stone samples.
5：Data Analysis Methods:
Morphological and constitutional analysis were performed using SEM and FTIR.
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