研究目的
To evaluate the structure–function relationship between disc margin–based rim area (DM-RA) obtained with confocal scanning laser tomography (CSLT), Bruch’s membrane opening–based horizontal rim width (BMO-HRW), minimum rim width (BMO-MRW), peripapillary retinal nerve fiber layer thickness (RNFLT) obtained with spectral-domain optical coherence tomography (SD-OCT), and visual field sensitivity.
研究成果
The structure–function relationship was enhanced with BMO-MRW compared with the other neuroretinal rim measurements, due mainly to its geometrically accurate properties.
研究不足
The study was limited to glaucoma patients with visual field damage characteristic of open angle glaucoma, with mean deviation between ?2 and ?10 dB, when first recruited for the longitudinal studies. The study did not include patients with nonglaucomatous ocular disease and systemic disease or systemic medication known to affect the visual field or ability to participate in the study.
1:Experimental Design and Method Selection:
The study examined 151 glaucoma patients with CSLT, SD-OCT, and standard automated perimetry on the same day. Optic nerve head (ONH) and RNFL with SD-OCT were acquired relative to a fixed coordinate system (acquired image frame [AIF]) and to the eye-specific fovea-BMO center (FoBMO) axis. Visual field locations were mapped to ONH and RNFL sectors with fixed Garway-Heath (VFGH) and patient-specific (VFPS) maps customized for various biometric parameters.
2:Sample Selection and Data Sources:
A total of 151 glaucoma patients were recruited from two ongoing longitudinal observational studies at the Eye Care Centre, Queen Elizabeth II Health Science Centre, Halifax, Nova Scotia, Canada.
3:List of Experimental Equipment and Materials:
Confocal scanning laser tomography (CSLT) (Heidelberg Retina Tomograph [HRT]; Heidelberg Engineering GmbH, Heidelberg, Germany), and SD-OCT (Spectralis; Heidelberg Engineering GmbH).
4:Experimental Procedures and Operational Workflow:
The ONH was imaged with CSLT and SD-OCT, and the peripapillary RNFL was imaged with SD-OCT.
5:Data Analysis Methods:
The relationship between global mean sensitivity (MS) and each of the global rim parameters, as well as that between the sectoral MS and the sectoral rim parameters, were assessed with linear regression. The strength of the relationship was evaluated with the coefficient of determination value (R2) of each model. Pearson correlation coefficients also were calculated.
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