研究目的
To develop a method to quantify, based on swept-source optical coherence tomography (OCT), the 3D structure of the laminar pores in patients with glaucoma.
研究成果
We successfully developed a method to quantify the 3D structure of the laminar pores; providing a useful tool to assess lamina cribrosa-associated risk factors for glaucoma. These findings promise to benefit future investigations into the pathomechanisms of glaucoma.
研究不足
The study had several limitations. First, the number of cases included was small. Second, the analysis process relied on manually marking the images. Third, the analysis process was very time-consuming.
1：Experimental Design and Method Selection:
The study used swept-source optical coherence tomography (OCT) to reconstruct 3D volume data for a 3 x 3 mm disc, similar to OCT angiography, and segmented the structure of the lamina cribrosa.
2：Sample Selection and Data Sources:
The study examined 160 laminar pores from 8 eyes of 8 cases: 4 normal subjects and 4 open-angle glaucoma (OAG) patients.
3：List of Experimental Equipment and Materials:
The study used VCAT5 (RIKEN, Japan) for manual segmentation of each laminar pore in sequential C-scan images.
4：Experimental Procedures and Operational Workflow:
The study manually segmented each laminar pore in sequential C-scan images (>90 slices at
5：6-micron intervals). Data Analysis Methods:
The study compared the control and OAG subjects with the Mann-Whitney U test. Differences were considered significant at p < 0.05.
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