研究目的
Investigating the propagation of elastically scattered and fluorescence light through biological tissue using a new parallel computational method based on the radiative transfer equation.
研究成果
The study demonstrates that the proposed Modified Finite Volume Method with an Exponential spatial differencing scheme can accurately predict light propagation in biological tissues, with relative differences less than 1.5% compared to Monte Carlo reference solutions. This method shows potential as a deterministic forward solver in optical tomography.
研究不足
The study acknowledges the computational costs and statistical errors associated with Monte Carlo methods and the challenges of numerical solutions for the RTE in three-dimensional geometries. The proposed method aims to mitigate these limitations but may still face challenges in highly anisotropic scattering media.
1：Experimental Design and Method Selection:
The study employs a Modified Finite Volume Method (MFVM) with a cell-vertex formulation and an Exponential spatial differencing scheme to solve the three-dimensional steady-state radiative transfer equation (RTE).
2：Sample Selection and Data Sources:
The model domain is a three-dimensional homogeneous cubic enclosure representing biological tissue, illuminated by a collimated incident beam.
3：List of Experimental Equipment and Materials:
The study uses computational spatial grids composed of nodes arranged along straight lines for structured grids.
4：Experimental Procedures and Operational Workflow:
The RTE is solved for both elastically scattered light and fluorescence light, with solutions validated against Monte Carlo (MC) reference solutions.
5：Data Analysis Methods:
The accuracy of the numerical method is assessed by comparing the solutions with MC reference solutions, focusing on the spatially resolved reflectance and fluorescence reflectance.
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