研究目的
To demonstrate a system-level integration of active silicon photonic biosensors for detecting small molecule interactions, specifically using a biotin-avidin affinity assay.
研究成果
The response of the high-compact low-cost biosensing system shows promising potential for small molecule detection, with a detection limit in the order of 10?5 M.
研究不足
The detection of small molecules is restricted due to the optical absorption of the continuous metal/dielectric surface, and sophisticated fabrication processes increase production costs.
1：Experimental Design and Method Selection:
The study employs a system-level architecture based on silicon photonic-electronic biosensors, utilizing a lab-scale Fan-Out Wafer-Level-Packaging (FOWLP) process.
2：Sample Selection and Data Sources:
A 1-mm2 silicon die integrated with 16 microring resonators (MRRs) and on-chip germanium photodetectors (PDs) is used.
3：List of Experimental Equipment and Materials:
Includes a tunable laser source, digital multimeter, syringe pump, and MATLAB for data analysis.
4：Experimental Procedures and Operational Workflow:
The biochip is electrically probed, and a Python script synchronizes the laser wavelength sweep with electrical measurements.
5：Data Analysis Methods:
MATLAB is used to fit the transmission spectra with a smoothing-spline function for high-resolution data analysis.
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