研究目的
To develop far-red/near-infrared emissive (1,3-dimethyl)barbituric acid-based AIEgens for high-contrast detection of metastatic tumors in lung.
研究成果
The highly FR/NIR fluorescent TPE-Th-B-doped AIE dots upon intravenous injection are capable of clearly visualizing pulmonary metastatic tumors and their boundaries to normal lung tissues during surgery with superb signal-to-background ratio and higher resolution than bioluminescence imaging of luciferase-expressed cancer cells. This study will inspire more exciting research in development of novel AIEgens/AIE dots for sophisticated biomedical utilizations.
研究不足
The lowest QY value of TPE-ETh-B-doped AIE dots should be attributed to the best water-solubility of TPE-ETh-B molecules caused by the incorporation of oxygen-containing ETh.
1：Experimental Design and Method Selection:
The D-π-A strategy was employed to design and synthesize low-bandgap AIEgens. Tetraphenylethene (TPE) was selected as the skeleton to reveal AIE. The methoxy-substituted TPE and (1,3-dimethyl)barbituric acid were used as the electron-donating and electron-withdrawing moiety, respectively. Between electron donor and acceptor, phenyl (Ph), thiophene (Th), or 3,4-ethylenedioxythiophene (ETh) were utilized as both the second donor and π-bridge, respectively, to increase the conjugation length.
2：Sample Selection and Data Sources:
The AIEgens were formulated into AIE dots using a nanoprecipitation method and an amphiphilic co-polymer lipid-PEG2000 as the doping matrix.
3：List of Experimental Equipment and Materials:
Dynamic light scattering (DLS) for nanoparticle size measurement, transmission electron microscopy (TEM) for morphology investigation, and UV-vis absorption and PL spectra for optical properties study.
4：Experimental Procedures and Operational Workflow:
The synthetic routes to compounds TPE-Ph-B, TPE-ETh-B, and TPE-Th-B are depicted in Scheme S
5：The AIE properties of TPE-Ph-B, TPE-Th-B, and TPE-ETh-B were studied. Data Analysis Methods:
The absolute PL QYs of the AIE dots were measured by a calibrated integrating sphere method.
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