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d-Glucose recognition based on phenylboronic acid-functionalized polyoligomeric silsesquioxane fluorescent probe
摘要： We report a new strategy to synthesize hybrid fluorescent nanosensors consisting of phenylboronic acid-functionalized POSS (POSS–PBA) and diol-modified 8-anilino-1-naphthalenesulfonic acid (ANSA (a fluorescent dye)) for the detection of the biologically important D-glucose. The probe was characterized by FT-IR and 1H-NMR analyses, and the photoluminescence intensity was measured under various conditions to confirm its glucose sensing ability. Our POSS-APBA-dye probe could detect glucose at concentrations of 0–20 mg/mL, with a good linear relationship even at low glucose concentrations of 0–1 mg/mL. The properties of the POSS-APBA-dye probe were evaluated and compared with those of an APBA-dye probe. The glucose sensing ability of our POSS-APBA-dye probe was largely unaffected by the presence of interfering substances. The probe showed high sensing ability in a pH 5 environment and long-term (approximately 40 days) fluorescence stability.
关键词： polyhedral oligomeric silsesquioxane,glucose sensor,fluorescence probe,boronic acid derivative
更新于2025-09-23 15:21:01
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1-D Metal-Dielectric-Metal Grating Structure as an Ultra-Narrowband Perfect Plasmonic Absorber in the Visible and Its Application in Glucose Detection
摘要： The need for an easy to fabricate perfect and narrowband light absorber in the visible range of electromagnetic (EM) spectrum has always been in demand for many scientific and device applications. Here, we propose a metal-dielectric-metal (MDM) 1-D grating plasmonic structure as a perfect narrow band light absorber in the visible and its application in glucose detection. The proposed structure consists of a 1- D grating of gold on the top of a dielectric layer on a gold film. Optimization for dielectric grating index (n), grating thickness (t), grating width (W), and grating period (P) has been done to improve the performance of plasmonic structure by calculating its quality factor and figure-of-merit (FOM). The optimized plasmonic structure behaves as a perfect narrowband light absorber. The flexibility to work at a specific wavelength is also offered by the proposed structure through an appropriate selection of the geometrical parameters and refractive index of the dielectric grating. The equivalent RC model is used to understand different components of the proposed structure on the optical response. The absorption response of the structure is invariant to the incident angle. Moreover, the calculated absorbance of the proposed plasmonic structure is ~ 100% with a narrow full-width half maxima (FWHM) of ~ 2.8 nm. We have numerically demonstrated a potential application of the proposed MDM absorber as a plasmonic glucose sensor in the visible range with detection sensitivity in the range of 140 to 195 nm/RIU.
关键词： Metal-dielectric-metal,Plasmons,Glucose detection,Optical sensors,Optical detectors,LC equivalent circuit
更新于2025-09-23 15:21:01
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A chemically modified laser-induced porous graphene based flexible and ultrasensitive electrochemical biosensor for sweat glucose detection
摘要： Porous laser-induced graphene (LIG) is an attractive and promising carbon material for electrochemical applications because it can immobilize various proteins, such as enzymes, antibodies, and receptors. However, poor inherent electrical properties caused by low surface conductivity is still a critical drawback for various applications. Here, we have proposed a surface modification method for the LIG electrode using acetic acid treatment via facile and practicable dipping technique. This simple acetic acid treatment dramatically increased the ratio of carbon-carbon bonds which effectively increased conductivity and decreased sheet resistance. Importantly, these unique properties also facilitated the stable and uniform dispersion of highly catalytic Pt nanoparticles (PtNPs) on LIG by avoiding the concentration of electric field on nanoparticles that can cause aggregation during electrodeposition. Finally, chitosan-glucose oxidase (GOx) composite was successfully immobilized onto the LIG/PtNPs electrode to fabricate a sweat glucose biosensor. The as-prepared LIG/PtNPs electrode exhibited a high sensitivity of 4.622 μA/mM as well as an ultra-low limit of detection (signal to noise ratio is 3) which was less than 300 nM and dynamic linear range up to 2.1 mM. Furthermore, we tested the variation of blood glucose level before and after meal using the amperometric response of the sensor which demonstrates the commercial potential of this unique sweat glucose biosensor.
关键词： Sweat glucose detection,Laser-induced graphene (LIG),Acetic acid treatment,Ultra-sensitive and -low detection limit,Electrochemical biosensor
更新于2025-09-23 15:19:57
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Femtosecond laser-induced non-thermal welding for a single Cu nanowire glucose sensor
摘要： Copper nanowires (CuNWs) are a key building block to facilitate carrier conduction across a broad range of nanodevices. For integration into nanoscale devices, manipulation and welding of these nanowires need to be overcome. Based on high energy density laser processing investigation, we report on innovative welding of single CuNWs to a silver film using a tightly focused laser beam combined with manipulation of CuNWs through the dielectrophoresis (DEP) method. Two types of lasers, femtosecond (FS) and continuous-wave (CW), were employed to analyze, improve, and control Cu-NW melting characteristics under high energy density irradiation. The FS laser welding of CuNWs resulted in a metallic joint with a low contact resistance suitable for functional electronic nanodevices. Computational simulations using the 1-D heat diffusion equation and finite difference method (FDM) were performed to gain an insight into metal–laser interactions for high performance welded contact development. Simulation studies on lasers established contrasting melting behavior of metal under laser irradiation. The device feasibility of CuNW based welded contacts was evaluated in terms of the electrical performance of a glucose sensor. It was possible to sense glucose concentration down to 10?6 M, demonstrating a path towards integration of CuNWs into wearable, flexible nanoelectronic devices.
关键词： glucose sensor,femtosecond laser,Copper nanowires,laser welding,dielectrophoresis,nanoelectronics,continuous-wave laser
更新于2025-09-23 15:19:57
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One-stop radiotherapeutic targeting of primary and distant osteosarcoma to inhibit cancer progression and metastasis using 2DG-grafted graphene quantum dots
摘要： The application of radiotherapy (RT) to treat osteosarcoma (OS) has been limited, but this is starting to change as the ability to target radiation energy to niches improves. Further, lung cancer from highly metastatic OS is a major cause of death, so it is critical to explore new strategies to tackle metastasis. In this study, we designed a nanoscale radiosensitizer by grafting 2-deoxy-d-glucose (2DG) on to graphene quantum dots (GQD) to achieve OS targeting and boost RT efficacy. Combining the use of 2DG-grafted GQDs (2DG-g-GQD) with RT produced a significant increase in oxidative stress response and DNA damage in the 143B OS cell line compared with RT alone. Moreover, 2DG-g-GQDs selectively associated with 143B cells, and demonstrated inhibition of migration in a scratch assay. We also demonstrated remarkable improvement in ability to inhibit tumour progression and lung metastasis in an OS xenograft mouse model. Our results show that the use of 2DG-g-GQDs as an OS-targeting radiosensitizer improves the therapeutic outcome and exhibits potential for use in low-dose precision RT for OS.
关键词： osteosarcoma,radiotherapy,metastasis,2-deoxy-d-glucose,graphene quantum dots
更新于2025-09-23 15:19:57
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Spherical Covalent-Organic Framework for Enhancing Laser Desorption/Ionization Mass Spectrometry of Small Molecules
摘要： A spherical vinyl-functionalized covalent-organic framework (COF-V) was room-temperature prepared by a facile method and applied as a novel substrate for surface-enhanced laser desorption/ionization mass spectrometry (SELDI-MS). Compared with conventional organic matrices, the spherical COF-V with high crystallinity and good monodispersity exhibited high sensitivity, no matrix background interference, wide-range applicability, high salt tolerance and reproducibility in the characterization of small molecules. On this basis, the applicability of the spherical COF-V-based SELDI-MS method was successfully demonstrated by determining trace glucose in diabetic urine, which would be a promising candidate for clinical diagnosis of diabetes. In addition, the morphological effect and desorption/ionization mechanism of COF-V were investigated in detail and the results indicated the spherical COF-V substrate could greatly enhance LDI process compared with bulk COF-V. This work not only extends the application of COFs in MS, but offers a promising alternative for small molecule identification and clinical diagnosis of diabetes.
关键词： spherical COF-V,clinical diagnosis,glucose,SELDI-MS,small molecules
更新于2025-09-23 15:19:57
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Low-cost and high sensitivity glucose sandwich detection using a plasmonic nanodisk metasurface
摘要： Glucose detection using Surface-enhanced Raman scattering (SERS) spectroscopy has aroused considerable attention due to its potential in the prevention and diagnosis of diabetes as a result of its unique molecular fingerprinting capability, ultrahigh sensitivity and minimal interference from water. Despite numerous solutions to improve the sensitivity of glucose detection, the development of a new SERS-based strategy to detect glucose with high sensitivity and low-cost is still required. In this study, we propose a simple and sensitive SERS-based plasmonic metasurface sensing platform for a glucose sandwich assay using self-assembled p-mercapto-phenylboronic acid (PMBA) monolayers on a gold nanodisk (Au-ND) metasurface and synthesized silver nanoparticles (Ag NPs) modified with a mixture of p-aminothiophenol (PATP) and PMBA. The localized near-field of the proposed plasmonic metasurface is markedly enhanced due to the coupling between the Au-ND and Ag NPs, which greatly improves detection sensitivity. The experimental results show that SERS signals of the glucose assay are significantly enhanced by more than 8-fold, in comparison with the SERS substrate of smooth Au film and Ag NPs. Moreover, the plasmonic metasurface-based glucose sandwich assay exhibits high selectivity and sensitivity for glucose over fructose and galactose. The developed plasmonic metasurface sensing platform shows enormous potential for highly sensitive and selective SERS-based glucose detection and opens a new avenue for scalable and cost-effective biosensing applications in the future.
关键词： Surface-enhanced Raman scattering (SERS),glucose detection,gold nanodisk (Au-ND),p-mercapto-phenylboronic acid (PMBA),p-aminothiophenol (PATP),silver nanoparticles (Ag NPs),plasmonic metasurface
更新于2025-09-23 15:19:57
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Laser-induced graphene hybrid photoelectrode for enhanced photoelectrochemical detection of glucose
摘要： The combination of electrocatalyst with semiconductor light-absorber is of great importance to increase the efficiency of photoelectrochemical (PEC) glucose detection. Here, in-situ and synchronous fabrication of Ni-based electrocatalyst (NiEC) and CdS semiconductor in laser-induced graphene (LIG) on indium?tin oxide glass is demonstrated via a one-step laser-induced solid phase transition. A series of component and structural characterizations suggest that the laser-induced NiEC uniformly disperses in the hybrid nanocomposite and exists mainly in the form of Ni0 and NiO state. Moreover, both electrochemical and PEC investigations confirm that the as-prepared hybrid photoelectrode exhibits excellent photoelectrocatalytic ability towards glucose, which is not only attributed to the strong synergistic interaction between CdS and NiEC, but also benefited from the high conductivity as well as 3D macroporous configuration of the simultaneously formed LIG, providing the key factor to achieve sensitive non-enzymatic PEC glucose sensors. Therefore, the laser-induced hybrid photoelectrode is then applied to the PEC detection of glucose, and a low detection limit of 0.4 μM is obtained with good stability, reproducibility, and selectivity. This study provides a promising paradigm for the facile and binder-free fabrication of electrocatalyst?semiconductor?graphene hybrid photoelectrode, which will find potential applications in sensitive PEC biosensing for a broad range of analytes.
关键词： nickel electrocatalyst,hybrid nanocomposite,cadmium sulfide,photoelectrochemical sensing,laser-induced graphene,glucose
更新于2025-09-23 15:19:57
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TiO2 nanotubes modified with polydopamine and graphene quantum dots as a photochemical biosensor for the ultrasensitive detection of glucose
摘要： Rapid and sensitive detection of glucose concentrations is very important for human health. Herein, an ultrasensitive photoelectrochemical dual-electron-acceptor biosensor was constructed by modifying the TiO2 nanotubes (NTs) with polydopamine (PDA) and amino-functionalized graphene quantum dots (N-GQDs)/GOx. PDA is grown on the top of the TiO2 NTs by the electropolymerization, and N-GQDs are loaded into the inner of the TiO2 NTs by a microwave-assisted method. The TiO2 NTs/PDA/N-GQD dual-electron-acceptor biosensor exhibited a highly enhanced photoelectric response, excellent electron–hole separation efficiency, low detection limit (0.015 mM), wide linear range (0–11 mM) and ultrahigh sensitivity (13.6 lA mM-1 cm-2). The prepared biosensor reflected high selectivity and excellent stability. This work also provides new insights into other optoelectronic biosensors.
关键词： photochemical biosensor,polydopamine,graphene quantum dots,TiO2 nanotubes,glucose detection
更新于2025-09-23 15:19:57
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Eco-friendly sugar-based natural deep eutectic solvents as effective electrolyte solutions for dye-sensitized solar cells
摘要： Dye-sensitized solar cells containing sugar-based Natural Deep Eutectic Solvents (NADESs) as active electrolyte solvents have been studied in their photovoltaic (PV) properties, including main PV characteristics, IPCE, and EIS. Five monosaccharides were selected as NADES H-bond donors and investigated with a phenothiazine-based sensitizer carrying a glucose functionality and a glucose-based co-adsorbent (glucuronic acid) to explore directional intermolecular interactions and improve the PV performance. The highest power conversion efficiencies were recorded for cells containing the glucose-based sensitizer in the presence of glucuronic acid in the sugar-based NADES. When one of these components was omitted, performances were lower suggesting that the best response came from an interplay between the sugar-based units. Not only has the unprecedented use of a NADES as a fully natural and bio-renewable DSSC medium been presented, but for the first time an active role of the electrolyte solvent has been reported and exploited to increase the performance of the solar device.
关键词： deep eutectic solvents,solar energy,glucose,hydrogen bond,photovoltaics
更新于2025-09-23 15:19:57