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[IEEE 2019 10th Workshop on Hyperspectral Imaging and Signal Processing: Evolution in Remote Sensing (WHISPERS) - Amsterdam, Netherlands (2019.9.24-2019.9.26)] 2019 10th Workshop on Hyperspectral Imaging and Signal Processing: Evolution in Remote Sensing (WHISPERS) - Discrete Wavelengths Screening Method for the Near-Infrared Spectroscopic Analysis of Serum Glucose
摘要： The spectral wavelength model optimisation is a fundamental core technology of near-infrared (NIR) spectroscopic analysis. An integrated optimisation method for wavelength selection of serum glucose analysis was proposed in the present study. A global parameter optimisation platform of Norris derivative filter (NDF) was established to achieve the most suitable equidistant preprocessing. combination-partial least squares (EC-PLS) combined with wavelength step-by-step phase-out-PLS (WSP-PLS) was proposed to achieve large-scale screening of discrete wavelengths model for serum glucose. As a result, the combination of eight wavelengths (1583, 1695, 1733, 1816, 1860, 2125, 2340, 2376 nm) was selected and a good prediction effect was obtained. It can provide a valuable reference for non-invasive blood glucose detection and designing dedicated spectrometers. The proposed WSP-PLS can optimise any wavelength model obtained by certain optimisation strategies, improve the prediction performance and reduce the wavelength model complexity. We believe it will have a wider application.
关键词： Near-infrared spectroscopy analysis,equidistant combination PLS,serum glucose,wavelength step-by-step phase-out-PLS,discrete wavelength screening
更新于2025-09-16 10:30:52
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Synergic effect of plasmonic gold nanoparticles and graphene oxide on the performance of glucose sensing
摘要： In this study hybrid nanostructures of Au–graphene oxide (Au–GO) were synthesized via a two-step process and used to modify the glassy carbon electrode (GCE) for electrochemical measurements of glucose. The modified electrode exhibits a fast response less than 4 s, a low detection limit of 0.025 mM and a high signal-to-noise ratio (S/N) of 3.5. The fabricated sensor shows a linear response in a large concentration range from 0.0025 mM to 15 mM with a reproducible sensitivity of 84.53 mA cm?2 mM?1, which is much higher than that of the individual Au, GO and previously reported GO/rGO based sensors. In addition, the biosensor shows excellent results for human serum which agree well with those obtained using a laboratory glucometer. Moreover, the glucose amount in selective commercially available food samples and fresh juices was also successfully measured. The biosensor exhibits excellent selectivity, thermal stability and reproducibility. The enhanced and efficient sensitivity of the developed Au–GO based biosensor may be due to the synergic effects of the plasmonic Au-nanoparticles and GO. The performance of the biosensor suggests that the reported Au–GO hybrid nanostructures can provide a novel platform for developing non-enzymatic biosensors for biomedical and industrial applications.
关键词： hybrid nanostructures,Au–graphene oxide,non-enzymatic biosensor,electrochemical measurements,glucose sensing
更新于2025-09-16 10:30:52
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A flexible non-enzymatic glucose sensor based on copper nanoparticles anchored on laser-induced graphene
摘要： An original flexible enzyme-free glucose amperometric biosensor based on Cu nanoparticles anchored on laser-induced graphene (Cu NPs-LIG) composite is successfully developed by a simple substrate-assisted electroless deposition (SAED) technique. The as-prepared Cu NPs-LIG sensor demonstrates an excellent glucose sensitivity of 495 μA mM-1 cm-2, ultrafast response time less than 0.5 s and the prominently low detection limit of 0.39 μM. Besides, the sensor shows extraordinary reproducibility, stability and selectivity in glucose sensing. Finally, a possible mechanism of the Cu NPs-LIG sensor for glucose sensing is proposed. Due to the simplicity preparation and performance reliability, the novel flexible Cu NPs-LIG sensor is an attractive candidate for next generation wearable and implantable non-enzymatic glucose diagnostic devices.
关键词： copper nanoparticles,non-enzymatic glucose sensor,electroless deposition,flexible,laser-induced graphene
更新于2025-09-16 10:30:52
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Photodynamic Therapy Versus Glucose for the Treatment of Telangiectasia: A Randomised Controlled Study in a Rabbit Ear Model
摘要： This experimental animal study shows that photodynamic therapy (PDT) of telangiectasia signi?cantly reduces the treated vein length and area temperature without causing severe histological damage, such as necrosis or ulceration. These preliminary ?ndings should stimulate further tests using this new approach for the treatment of telangiectasia.
关键词： Hypertonic glucose solution,Photodynamic therapy,Telangiectasia,Rabbit ear model
更新于2025-09-16 10:30:52
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Laser method of microscopic sensor synthesis for liquid and gas analysis using glucose and H2S as an example
摘要： Laser-induced deposition of metals from a solution has been used as a new method for the synthesis of microcomposite materials in the copper-silver system. It was shown that the obtained materials have good sensory properties with respect to the determination of D-glucose in aqueous solutions. It is also shown that it can be used for gas sensors. Control of sensory properties can be done by changing the method of deposition. X-ray diffraction, EDX, and impedance spectroscopy were used to characterize the materials obtained and it was shown that laser sequential deposition and coprecipitation of two metals give different results. An explanation of the results was proposed. It explains them by the eutectic nature of the interaction in the copper-silver system.
关键词： copper-silver system,impedance spectroscopy,D-glucose,EDX,sensory properties,X-ray diffraction,Laser-induced deposition,microcomposite materials,gas sensors
更新于2025-09-12 10:27:22
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[IEEE 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII) - Berlin, Germany (2019.6.23-2019.6.27)] 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII) - Functional Plasmonic Fiber-Optic Based Sensors Using Low-Cost Microsphere Photolithography
摘要： This paper presents a technique for the low-cost fabrication of plasmonic fiber-optic based refractive-index sensors. The Microsphere Photolithography (MPL) technique was used to pattern nanoholes in a thin aluminum to create Extraordinary Optical Transmission (EOT) based sensors on the cleaved tip of SMF-28 optical fibers. This technique uses self-assembled microspheres as an optical element and facilitates very low-cost patterning of the plasmonic probes. As the refractive index of the media changes, the reflected spectrum of optical fiber changes. The fabricated sensors were immersed in water with different concentrations of glucose, and the lowest detection limit was found to be 33 mg/mL.
关键词： Fiber,Glucose detection,Microsphere photolithography,Plasmonic sensor
更新于2025-09-12 10:27:22
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Surface Engineering of Laser-Scribed Graphene Sensor Enables Non-Enzymatic Glucose Detection in Human Body Fluids
摘要： Contemporary devices for glucose monitoring predominantly rely on finger-pricked blood through an enzyme-catalyzed reaction. However, the enzymes are highly expensive, unstable and require complex procedures for integration with the sensing matrix, rendering strategic replacement by non-enzymatic sensors. Here, a non-enzymatic glucose sensor is developed based on surface engineering of laser scribed graphene (LSG) - an immerging 3D patterned graphene - that combines binder-free, highly porous, conducting graphitic carbon network. An easy and green method is developed to engineer LSG surface by conformal anchoring of copper oxide nanoparticles (CuO NPs) of optimized NP size for enhancing its catalytic efficacy. The device shows excellent non-enzymatic glucose sensing performance (0.4 V detection potential vs. printed Ag/AgCl reference electrode, ? 0.2 s response time, 0.1 μM detection limit, 1 μM-5 mM linearity and high selectivity). Noteworthy, the device exhibits high stability and reproducibility for glucose in human body fluids (whole blood, serum, sweat, and urine). In addition, conformal transfer of LSG to commercial scotch tape (LSGST) enables wearability of the device on curvilinear body parts, exemplified through miniaturized devices monitoring glucose in sweat directly. These findings pave a new path for a comprehensive personalized healthcare strategy by accurate non-enzymatic detection of glucose from human body fluids.
关键词： Laser-scribed graphene,Miniaturized device,Glucose,Scotch tape,Non-enzymatic sensor
更新于2025-09-12 10:27:22
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Laser and thermal dewetting of gold layer onto graphene paper for non-enzymatic electrochemical detection of glucose and fructose
摘要： Electrochemical non-enzymatic detections of glucose and fructose were based on gold nanoparticles (AuNPs) onto graphene paper. Electrodes based on AuNPs have been obtained inducing dewetting, by thermal (furnace) or by laser, of sputter deposited 8 nm-thick Au layer onto graphene paper. The electrodes were characterized by Scanning Electron Microscopy, Micro Raman Spectroscopy, X-ray Diffraction, Rutherford back-scattering Spectroscopy and Cyclic Voltammetry. The main difference exhibited by thermal and laser dewetting processes lies in the size and shape of the resulting gold nanoparticles. Laser dewetting originates smaller particles than that obtained by thermal dewetting. The particles are almost spherical and mainly localized onto graphene nanoplatelets. The size of AuNPs is in the ranges 10–150 nm. Electrodes obtained by thermal process present gold nanostructures characterized by faceted AuNPs. Typical sizes are in the range of 20–40 and 200–400 nm. The electrocatalytic activity toward glucose and fructose oxidation in alkaline phosphate buffer solution are presented and discussed. Glucose was detected at a potential of 0.17 V (laser dewetting) or 0.19 V (thermal dewetting) vs SCE, which corresponds to the intense peak of two electrons oxidation. Fructose was detected at potential of 0.4 V vs SCE. Sensitivity up to 1240 μA mM?1 cm?2 for glucose detection was obtained. The resulting analytical performances for glucose and fructose detection are very promising since comparable to the actual state of art for nanostructured gold electrodes which are, however, produced by complex multi-steps wet processes and/or enzymes.
关键词： Glucose,Gold nanoparticles,Graphene paper,Fructose electrochemical detection
更新于2025-09-12 10:27:22
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Laser-Scribed Graphene Electrodes Derived from Lignin for Biochemical Sensing
摘要： Laser scribing of porous graphene electrodes on flexible substrates is of great interest for developing disposable electrochemical biosensors. In this work, we present a new patterning process for highly conductive nitrogen-doped graphene derived from a lignin-based precursor. A CO2 laser scribing process was performed under ambient conditions to produce the porous graphene electrodes from lignin. The obtained nitrogen-doped laser-scribed graphene (N-LSG) is binder-free, hierarchical, and conductive. The interconnected carbon network displayed enhanced electrochemical activity with improved heterogeneous electron transfer rate. These features can be attributed to the high-conductivity of porous N-LSG (down to 2.8 ? per square) and its enriched active edge plane sites. Furthermore, the N-LSG electrodes were decorated with MXene/Prussian Blue (Ti3C2Tx/PB) composite via a simple spray coating process, designed for sensitive detection of analytes. The Ti3C2Tx/PB modified N-LSG electrodes were functionalized with catalytic enzymes for detecting glucose, lactate, and alcohol. The enzyme/Ti3C2Tx/PB/N-LSG electrodes exhibited remarkably enhanced electrochemical activity toward the detection of these biomarkers, making them highly competitive with previously reported on-chip carbon-based biosensors. Therefore, our sensors demonstrate excellent potential for applications in personalized healthcare.
关键词： laser-scribed graphene,MXene,alcohol,lactate,glucose,lignosulfonate,biosensor,high conductivity
更新于2025-09-12 10:27:22
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A Quantum Dot-Based FLIM Glucose Nanosensor
摘要： In the last few years, quantum dot (QD) nanoparticles have been employed for bioimaging and sensing due to their excellent optical features. Most studies have used photoluminescence (PL) intensity-based techniques, which have some drawbacks, especially when working with nanoparticles in intracellular media, such as fluctuations in the excitation power, fluorophore concentration dependence, or interference from cell autofluorescence. Some of those limitations can be overcome with the use of time-resolved spectroscopy and fluorescence lifetime imaging microscopy (FLIM) techniques. In this work, CdSe/ZnS QDs with long decay times were modified with aminophenylboronic acid (APBA) to achieve QD-APBA conjugates, which can act as glucose nanosensors. The attachment of the boronic acid moiety on the surface of the nanoparticle quenched the PL average lifetime of the QDs. When glucose bonded to the boronic acid, the PL was recovered and its lifetime was enhanced. The nanosensors were satisfactorily applied to the detection of glucose into MDA-MB-231 cells with FLIM. The long PL lifetimes of the QD nanoparticles made them easily discernible from cell autofluorescence, thereby improving selectivity in their sensing applications. Since the intracellular levels of glucose are related to the metabolic status of cancer cells, the proposed nanosensors could potentially be used in cancer diagnosis.
关键词： fluorescence lifetime imaging,intracellular sensing,quantum dots,nanoparticles,glucose,photoluminescence
更新于2025-09-11 14:15:04