- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
COUPLED LINE RAT-RACE COUPLER WITH WIDE ADJUSTABLE POWER DIVIDING RATIO AND UNCROSSED INPUT/OUTPUT PORTS
摘要： A novel rat-race coupler with wide adjustable range of power-dividing ratio and uncrossed input/output ports is presented by using coupling adjustable trans-directional (TRD) coupled lines, parallel coupled lines and a 180? phase shifting line. Wide adjustable range of power-dividing ratios is accomplished by varying the coupling of the TRD coupled lines. Moreover, with the combination of the TRD coupled lines and parallel coupled lines, the input and output ports of the rat-race coupler are uncrossed. The structure of the proposed rat-race coupler is analyzed, and the design equations are derived. As an example to validate the feature of the proposed rat-race coupler, a prototype operating at 1.6 GHz is devised, fabricated and measured. The measured results show that the designed coupler has a wide adjustable range (?7 ～ 15 dB) of power dividing ratio with a controlled voltage range of 3.3 to 13.5 V.
关键词： rat-race coupler,parallel coupled lines,TRD coupled lines,uncrossed input/output ports,180? phase shifting line,adjustable power-dividing ratio
更新于2025-09-12 10:27:22
-
Application of quantum dot‐based biosensor to the conjunctiva in Wistar albino rats
摘要： This study was conducted to get an idea about the distribution of the lymphatic fluid in conjunctiva throughout the body parts. For this purpose, Qdot655 (QD), fluorescence nanoparticles, spread onto the conjunctiva were used on Wistar albino rats. Drainage of QD particles from conjunctiva was followed up via fluorescence images at different hours on body parts such as eye, ears, forearms, hind legs and tails. The first fluorescence signals within the 30th minutes following administration of QD were observed in the nasal region and the anterior extremities. Whereas within 60th minutes following QD spread, fluorescent signals were obtained from the ears, forearms, hind legs and tail of the female and male rats.
关键词： rat,conjunctiva,quantum dot,biosensor,in vivo imaging,eyelid lymphatics
更新于2025-09-11 14:15:04
-
Ultra-Compact Tunable Filtering Rat-Race Coupler Based on Half-Mode SIW Evanescent-Mode Cavity Resonators
摘要： In this paper, for the first time, an ultra-compact frequency-tunable filtering rat-race coupler based on half-mode evanescent-mode (EVA) cavity resonators is presented. Employing EVA cavity resonators in the coupler design yields attractive characteristics, such as a wide tuning range and a wide spurious-free range, while also adding filtering functionality to the device. The presented coupler is synthesized as a two pole bandpass filter using the coupling matrix method. Then, the coupling coefficients are mapped to a coupler topology. Design, simulations, and experimental validation are presented. The implemented rat-race coupler has a very compact size [0.14λg × 0.14λg (λg at 885 MHz)] achieving a 92% miniaturization in the structure footprint compared to the conventional planar one. The coupler has an 86% tuning range ranging between 0.885–1.65 GHz. Throughout the tuning range, the coupler shows an equal power splitting ratio and filtering profile with a measured insertion loss and 3-dB fractional bandwidth between 5 and 4.2 dB and 6.8% and 8%, respectively. The measured isolation is better than 30 dB. In addition, the coupler has a measured spurious-free range of 10.2 fo (at the lowest frequency) to 5.45 fo (at the highest frequency).
关键词： rat-race coupler,tunable resonators,Evanescent-mode (EVA) cavity,tunable coupler,half-mode
更新于2025-09-11 14:15:04
-
Theory and Design of a Retrodirective Rat-Race-Based RFID Tag
摘要： Movement towards mm-wave backscatter communications in radio-frequency identification (RFID) systems necessitates seeking designs that compensate for the path loss introduced by the radio channel. A viable, simple, and power-efficient solution is to equip RFID tags with retrodirective arrays, which guarantee reflection with maximal gain in the direction of incidence. In this paper, we build upon a previous work to design and implement an original retrodirective tag in which its feeding network is a properly-terminated rat-race coupler. We start by deriving the required terminations that ensure retrodirectivity. Then, we build a retrodirective tag and experimentally compare its radar cross section to that of a single-antenna tag. The measurements reveal that the radar cross section of the proposed retrodirective tag is, on average, approximately 6 dB more than that of a single-antenna tag while both tags have the same field-of-view. From the promising results in this paper, the proposed design is a potential candidate for next-generation microwave and mm-wave RFID tags because it is compatible with low-power reflection amplifiers (e.g., tunnel diodes), it can implement multiple modulation schemes without changing the circuit layout, and it can be implemented using only a single RF switch.
关键词： multi-modulation RFID tags,Retrodirective arrays,rat-race coupler
更新于2025-09-09 09:28:46
-
Improvement in infected wound healing in type 1 diabetic rat by the synergistic effect of photobiomodulation therapy and conditioned medium
摘要： We investigated the effects of photobiomodulation therapy (PBMT) and conditioned medium (CM) of human bone marrow mesenchymal stem cells (hBM‐MSC) individually and/or in combination on the stereological parameters and the expression of basic fibroblast growth factor (bFGF), hypoxia‐inducible factor (HIF‐1α), and stromal cell–derived factor‐1α (SDF‐1α) in a wound model infected with methicillin‐resistant Staphylococcus aureus (MRSA) in diabetic rats. CM was provided by culturing hBM‐MSCs. Type 1 diabetes mellitus (T1DM) was induced in 72 rats, divided into four groups, harboring 18 rats each: group 1 served as a control group, group 2 received PBMT, group 3 received CM, and group 4 received CM + PBMT. On days 4, 7, and 15, six animals from each group were euthanized and the skin samples were separated for stereology examination and gene expression analysis by real‐time polymerase chain reaction. In the CM + PBMT, CM, and PBMT groups, significant decreases were induced in the number of neutrophils (1460 ± 93, 1854 ± 138, 1719 ± 248) and macrophages (539 ± 69, 804 ± 63, 912 ± 41), and significant increases in the number of fibroblasts (1073 ± 116, 836 ± 75, 912 ± 41) and angiogenesis (15 230 ± 516, 13 318 ± 1116, 14 041 ± 867), compared with those of the control group (2690 ± 371, 1139 ± 145, 566 ± 90, 12 585 ± 1219). Interestingly, the findings of the stereological examination in the CM + PBMT group were statistically more significant than those in the other groups. In the PBMT group, in most cases, the expression of bFGF, HIF‐1α, and SDF‐1α, on day 4 (27.7 ± 0.14, 28.8 ± 0.52, 27.5 ± 0.54) and day 7 (26.8 ± 1.4, 29.6 ± 1.4, 28.3 ± 1.2) were more significant than those in the control (day 4, 19.3 ± 0.42, 25.5 ± 0.08, 22.6 ± 0.04; day 7, 22.3 ± 0.22, 28.3 ± 0.59, 24.3 ± 0.19) and other treatment groups. The application of PBMT + CM induced anti-inflammatory and angiogenic activities, and hastened wound healing process in a T1 DM model of MRSA infected wound.
关键词： stereology,diabetes mellitus,diabetic foot ulcer,methicillin‐resistant staphylococcal aureus,low‐level laser therapy,phobiomodulation therapy,human bone marrow mesenchymal stem cell‐conditioned medium,real‐time PCR,rat
更新于2025-09-04 15:30:14
-
Spatiotemporal Expression Changes of PACAP and Its Receptors in Retinal Ganglion Cells After Optic Nerve Crush
摘要： Pituitary adenylate cyclase-activating polypeptide (PACAP) has been demonstrated to play a crucial part in protecting retinal ganglion cells (RGCs) from apoptosis in various retinal injury animal models. PACAP has two basic groups of receptors: PACAP receptor type 1 (PAC1R) and vasoactive intestinal polypeptide/PACAP receptors (VPAC1R and VPAC2R). However, few studies illustrated the spatial and temporal expression changes of endogenous PACAP and its receptors in a rodent optic nerve crush (ONC) model. In this study, a significant upregulation of PACAP and PAC1R in the retina after ONC was observed in both protein and RNA levels. The peak level of PACAP and PAC1R expression could be found on the fifth day following ONC. In addition, immunofluorescent labeling indicated that PACAP and PAC1R were localized mainly in RGCs. On the contrary, VPAC1R and VPAC2R were hardly detected in the retina. Collectively, the spatiotemporal expression of PACAP and its high-affinity receptor PAC1R were remarkably changed after ONC, and mainly expressed in the ganglion cell layer of the retina. This suggested that the upregulation of PACAP and PAC1R may play a vital role in RGC death after ONC.
关键词： PACAP,Receptors,Rat,Retinal ganglion cells,Optic nerve crush
更新于2025-09-04 15:30:14
-
Optical coherence tomography imaging of the basal ganglia: feasibility and brief review
摘要： Optical coherence tomography (OCT) is a promising medical imaging technique that uses light to capture real-time cross-sectional images from biological tissues in micrometer resolution. Commercially available optical coherence tomography systems are employed in diverse applications, including art conservation and diagnostic medicine, notably in cardiology and ophthalmology. Application of this technology in the brain may enable distinction between white matter and gray matter, and obtainment of detailed images from within the encephalon. We present, herein, the in vivo implementation of OCT imaging in the rat brain striatum. For this, two male 60-day-old rats (Rattus norvegicus, Albinus variation, Wistar) were stereotactically implanted with guide cannulas into the striatum to guide a 2.7-French diameter high-definition OCT imaging catheter (Dragonfly, St. Jude Medical, USA). Obtained images were compared with corresponding histologically stained sections to collect imaging samples. A brief analysis of OCT technology and its current applications is also reported, as well as intra-cerebral OCT feasibility on brain mapping during neurosurgical procedures.
关键词： Basal ganglia,Optical coherence tomography (OCT),Rat brain,Histology,Thalamus,Brain imaging
更新于2025-09-04 15:30:14
-
The Neuroprotective Effect of Maltol against Oxidative Stress on Rat Retinal Neuronal Cells
摘要： Purpose: Maltol (3-hydroxy-2-methyl-4-pyrone), formed by the thermal degradation of starch, is found in coffee, caramelized foods, and Korean ginseng root. This study investigated whether maltol could rescue neuroretinal cells from oxidative injury in vitro. Methods: R28 cells, which are rat embryonic precursor neuroretinal cells, were exposed to hydrogen peroxide (H2O2, 0.0 to 1.5 mM) as an oxidative stress with or without maltol (0.0 to 1.0 mM). Cell viability was monitored with the lactate dehydrogenase assay and apoptosis was examined by the terminal deoxynucleotide transferase-mediated terminal uridine deoxynucleotidyl transferase nick end-labeling (TUNEL) method. To investigate the neuroprotective mechanism of maltol, the expression and phosphorylation of nuclear factor-kappa B (NF-κB), extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 were evaluated by Western immunoblot analysis. Results: R28 cells exposed to H2O2 were found to have decreased viability in a dose- and time-dependent manner. However, H2O2-induced cytotoxicity was decreased with the addition of maltol. When R28 cells were exposed to 1.0 mM H2O2 for 24 hours, the cytotoxicity was 60.69 ± 5.71%. However, the cytotoxicity was reduced in the presence of 1.0 mM maltol. This H2O2-induced cytotoxicity caused apoptosis of R28 cells, characterized by DNA fragmentation. Apoptosis of oxidatively-stressed R28 cells with 1.0 mM H2O2 was decreased with 1.0 mM maltol, as determined by the TUNEL method. Western blot analysis showed that treatment with maltol reduced phosphorylation of NF-κB, ERK, and JNK, but not p38. The neuroprotective effects of maltol seemed to be related to attenuated expression of NF-κB, ERK, and JNK. Conclusions: Maltol not only increased cell viability but also attenuated DNA fragmentation. The results obtained here show that maltol has neuroprotective effects against hypoxia-induced neuroretinal cell damage in R28 cells, and its effects may act through the NF-κB and mitogen-activated protein kinase signaling pathways.
关键词： Oxidative stress,Neuroprotection,Maltol,Rat retinal neuronal cell
更新于2025-09-04 15:30:14
-
A novel experimental approach for liver analysis in rats exposed to Bisphenol A by means of LC-mass spectrometry and infrared spectroscopy
摘要： An innovative complementary approach using a liquid chromatographic-mass spectrometer method and infrared spectroscopy is proposed for measuring internal biological exposure to dangerous chemical contaminants and for monitoring biochemical changes in target organs. The proposed methodologies were validated and applied in the case of rats exposed to low-doses of Bisphenol A (BPA). A liquid chromatographic method coupled to a tandem mass spectrometer was used in order to measure BPA concentration in rat livers. BPA was detected at different levels in all liver samples from BPA-treated rats, although the exposure dose was the same in all treated animals, and also from control rats, highlighting the difficulties in eliminating external uncontrolled exposure and the need for internal biological monitoring. Fourier Transform Infrared analysis was applied to detect structural changes occurring in several molecules (lipids, proteins, carbohydrates and nucleic acids) as well as the presence of specific metabolic processes. The spectroscopic analyses clearly demonstrated a different lipid composition more than an evident lipid accumulation and a glycogen accumulation decrease, revealing a metabolic disturbance in livers with a normal histological aspect. These results demonstrated the potential of an integrated approach based on mass spectrometry and infrared spectroscopy to evaluate at an early stage the hepatotoxic effect of BPA exposure in an animal model. This approach can be usefully exploited in all the investigations aimed to provide better information concerning the interrelationships between contaminant exposure, dose, and health effects.
关键词： Bisphenol A exposure,Metabolic disturbance,Rat liver,Mass spectrometry,Infrared spectroscopy
更新于2025-09-04 15:30:14