研究目的
To evaluate the characteristics and relationship between peripapillary choroidal thickness (pCT), lamina cribrosa thickness (LCT), and peripapillary outer retinal layer thickness (pORT) as determined using spectral domain optical coherence tomography (SD-OCT) enhanced depth imaging (EDI).
研究成果
The pCT is substantially thinner in the inferior area of the ONH. In addition, the pCT demonstrates the strongest correlation with age and AXL, but was not associated with glaucoma or LCT.
研究不足
The variability of CT measurements may affect the outcome of CT studies. The current assessment of LCT is limited to the relatively central area of the LC.
1：Experimental Design and Method Selection:
The study included 255 participants (87 healthy subjects, 87 glaucoma suspects, and 81 glaucoma cases). pORT and pCT were manually measured using EDI scanning of the circumpapillary retinal nerve fiber layer (RNFL). LCT was determined by EDI scanning of the optic nerve head (ONH).
2：Sample Selection and Data Sources:
Participants were prospectively and consecutively recruited from a glaucoma clinic and examined between February 2011 and November
3：List of Experimental Equipment and Materials:
20 Spectralis SD-OCT (Heidelberg Engineering), Humphrey field analyzer (HFA) Swedish Interactive Threshold Algorithm 24-2 testing (Carl Zeiss Meditec), IOLMaster (Carl Zeiss Meditec), DGH-1000 Ultrasonic Pachymeter (DGH Technology).
4：Experimental Procedures and Operational Workflow:
Participants underwent a complete ophthalmologic examination, including visual acuity testing, IOP measurements, stereoscopic optic disc photography, AXL and CCT determination, and SD-OCT imaging.
5：Data Analysis Methods:
ANOVA (post hoc analysis, Tukey’s test) was performed to compare the baseline characteristics and SD-OCT measurements of the three groups. Correlations between putative factors and pCT were determined using univariate and multivariate linear regression analyses.
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