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Novel fluorescent sensor using molecularly imprinted silica microsphere‐coated CdSe@CdS quantum dots and its application in the detection of 2,4,6‐trichlorophenol from environmental water samples
摘要： In this study, a high fluorescence sensitivity and selectivity, molecularly imprinted nanofluorescent polymer sensor (MIP@SiO2@QDs) was prepared using a reverse microemulsion method. 2,4,6-Trichlorophenol (2,4,6-TCP) was detected using fluorescence quenching. Tetraethyl orthosilicate (TEOS), quantum dots (QDs) and 3-aminopropyltriethoxysilane (APTS) were used as cross-linker, signal sources and functional monomer respectively. The sensor (MIP@SiO2@QDs) and the non-imprinted polymer sensor (NIP@SiO2@QDs) were characterized using infra-red (IR) analysis, X-ray diffraction (XRD), transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The selectivity of MIP@SiO2@QDs was examined by comparing 2,4,6-TCP with other similar functional substances including 2,4-dichlorophenol (2,4-DCP), 2,6-dichlorophenol (2,6-DCP) and 4-chlorophenol (4-CP). Results showed that MIP@SiO2@QDs had better selectivity for 2,4,6-TCP than the other compounds. Fluorescence quenching efficiency displayed a good linear response at the 2,4,6-TCP concentration range 5–1000 μmol/L. The limit of detection (LOD) was 0.9 μmol/L (3σ, n = 9). This method was equally applicable for testing actual samples with a recovery rate of 98.0–105.8%. The sensor had advantages of simple pretreatment, good sensitivity and selectivity, and wide linear range and could be applied for the rapid detection of 2,4,6-TCP in actual samples.
关键词： quantum dots,2,4,6-trichlorophenol,fluorescence,molecularly imprinted polymers
更新于2025-11-19 16:46:39
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Phosphorimetric determination of 4-nitrophenol using mesoporous molecular imprinting polymers containing manganese(II)-doped ZnS quantum dots
摘要： Mesoporous molecularly imprinted polymers (MIPs) containing mangnanese-doped ZnS quantum dots (Mn-ZnS QDs) were prepared for specific recognition and detection of 4-nitrophenol (4-NP). The Mn-ZnS QDs display orange room-temperature phosphorescence with excitation/emission peaks at 295/590 nm and a decay time of 2.0 ms. In the presence of 4-NP, the orange phosphorescence is strongly reduced. Phosphorescence drops linearly in the 0.1–100 μM 4-NP concentration range, and the detection limit is 60 nM. The detection limit is far lower than the maximally allowed 4-NP concentrations in surface water and drinking water as specified by the U.S. Environmental Protection Agency. The intraday (n = 5) and interday (n = 6) spiked recovery rates were 96.0–104.5% and 97.9–107.9%, respectively, with relative standard deviations of 0.7–4.8% and 1.8–7.5% respectively. These MIPs integrated the characteristic features of phosphorimetry and molecular imprinting. Potential interference by competitive substances, background fluorescence or scattered light are widely reduced.
关键词： Room-temperature phosphorescence,Mesoporous molecularly imprinted polymers,Photoinduced electron-transfer,4-Nitrophenol,Decay time
更新于2025-11-14 17:04:02
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Preparation and comparison of molecularly imprinted polymer fluorimetric nanoprobe based on polymer dots and carbon quantum dots for determination of acetamiprid using response surface method
摘要： In this study molecularly imprinted polymers (MIP) based on carbon quantum dots (CQDs) and polymer dots (PDs) are developed for selective determination of acetamiprid using fluorometry. The measurement is based on the fluorescence quenching of CQDs and PDs in the presence of acetamiprid. PDs were prepared using a one-step aqueous synthesis method from ascorbic acid and diethylenetriamine at room temperature. CQDs were prepared from the same materials using the hydrothermal method at 180 °C. These particles were characterized using field emission scanning electron microscopy (FE-SEM), FTIR, dynamic light scattering (DLS), X-ray diffraction (XRD), UV–Vis, and fluorescence. The quantum yield was 47% for PDs and 8% for CQDs. Then, molecularly imprinted polymers (MIP) were prepared based on PDs and CQDs using reverse microemulsion method. The fluorescence quenching of CQD@MIPs and PD@MIPs was investigated at an excitation wavelength of 350 nm and emission wavelength of 440 nm in the presence of a template. Other variables affecting the fluorescence peaking were optimized using design expert software. The results illustrate that the use of PD@MIPs had a wide dynamic range 0.08–109 nmol L?1, good accuracy and detection limit of 0.02 nmol L?1, while using CQD@MIPs led to a lower dynamic range 0.36–64 nmol L?1, and detection limit of only 0.11 nmol L?1. The responses of the optical nanoprobe for acetamiprid in water (recovery 92–102%) and apple (recovery 92–103%) were also investigated.
关键词： Molecularly imprinted polymers,Fluorescence quencing,Carbon dots,Polymer dots,Optical nanoprobe,Acetamiprid
更新于2025-09-23 15:21:01
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One-step electrosynthesized molecularly imprinted polymer on laser scribed graphene bisphenol a sensor
摘要： Bisphenol A (BPA) is a toxic chemical used by industries for production of containers for storage of food and beverages leading to possible health risks. In this work, we present a simple, mask-free, low-cost imprinted sensor based on laser scribed graphene (LSG) technology combined to molecularly imprinted polymers (MIPs) for BPA determination. CO2 laser was used in production of LSG electrodes with high resistivity 58 Ω/square on flexible polyimide sheet leading to the high active surface area of the sensor. LSG device was functionalized with imprinted polypyrrole with a known amount of BPA as template molecule to develop the sensor. The bare LSG, LSG-MIP, LSG-NIP sensors were characterized using Raman spectroscopy, SEM, XRD, AFM. The electrochemical measurements were carried out using cyclic voltammetry and differential pulse voltammetry. Experimental conditions were optimized, including the concentration of pyrrole monomer, the number of polymerization cycles, the concentration of BPA as template and the incubation time. We evaluated the sensitivity of the LSG-MIP sensor in the concentration range between 0.05 μM and 20 μM with a limit of detection of 8 nM. The proposed sensor exhibits high selectivity towards BPA compared to its structural analogs and good reusability. The developed sensor was successfully applied for the detection of BPA in tap, mineral water and in plastic samples. The developed sensor was integrated into a PMMA case connected to the potentiostat to achieve complete isolation and a practical measurement system.
关键词： Molecularly imprinted polymers,Water samples,Electropolymerization,Electrochemical devices,Bisphenol A,Laser scribed graphene
更新于2025-09-23 15:21:01
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[IEEE 2018 2nd International Conference on Biomedical Engineering (IBIOMED) - Bali, Indonesia (2018.7.24-2018.7.26)] 2018 2nd International Conference on Biomedical Engineering (IBIOMED) - Design of Mass-Sensitive Sensor Array for Biomedical Application: Sensing Lipoproteins
摘要： Herein we report the design of a novel sensor array based on molecularly imprinted polymer (MIP) for low-density lipoprotein (LDL) and high-density lipoprotein (HDL) determination. MIP of each lipoprotein class comprising co-monomer of methacrylic acid (MAA) and vinyl pyrrolidone (NVP) in the ratio of 3:2 and 2:3, were screened onto three-electrode quartz crystal microbalance (QCM) as selective elements toward LDL and HDL, respectively. Sensor array device reveals concentration-dependent sensor responses toward varying amount of each standard LDL and HDL solution with a linear correlation coefficient of R2 = 0.89 and 0.99, respectively. HDL-MIP presents cross-reactivity to LDL at 9-19% compared to the LDL-MIP signal. LDL-MIP also has cross-reactivity to HDL at 0-3% of LDL-MIP responses. All sensor signals are fully reversible and the sensor array can be reused.
关键词： molecularly imprinted polymers,low-density lipoprotein,high-density lipoprotein,QCM sensor array
更新于2025-09-23 15:21:01
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Preparation of molecularly imprinted fluorescence sensor based on carbon quantum dots via precipitation polymerization for fluorescence detection of tetracycline
摘要： A facile and effective method was proposed to prepare the molecularly imprinted fluorescence sensor with carbon quantum dots, which were modified vinyl groups by acrylic acid on the surface. The obtained fluorescence composite material was investigated by transmission electron microscope and Fourier transform infrared spectra. After the experimental conditions were optimized, a linear range of 1.0–60 μmol L?1 was obtained and the detection limit was 0.17 μmol L?1. The novel fluorescence sensor can be successfully used to detect tetracycline in real samples. This study provides a convenient strategy for selective recognition and rapid detection of tetracycline in the complex environment.
关键词： precipitation polymerization,tetracycline,carbon quantum dots,molecularly imprinted polymers,fluorescence detection
更新于2025-09-23 15:19:57
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Sensing of Furfural by Molecularly Imprinted Polymers on Plasmonic and Electrochemical Platforms
摘要： The goal of this work is to test the possibility of selective detection of furfural (2-FAL) in aqueous solutions, with a molecularly imprinted polymer (MIP) receptor exploiting two different transduction methods, for food safety applications. In particular, sensors with electrochemical and surface plasmon resonance (SPR) transduction are considered. Two concentration ranges could be investigated by the different sensing approaches since the detectable concentration level depends on the sensitivity of the detection technique employed. The determination of 2-FAL at different concentration levels in the aqueous medium of interest, as for example beverages, is becoming a very crucial task not only for the relevance of furanic compounds in affecting the flavor but also for their possible toxic and carcinogenic effects on the human beings. For these reasons, their determination by a fast, easy and low-cost method is of interest. The sensor methods here proposed appears to be particularly suitable, since, although together and not individually, they allow the determination in a wide concentration range.
关键词： furfural (2-FAL),electrochemical sensors,molecularly imprinted polymers (MIPs),optical-chemical sensors,plastic optical fibers (POFs),surface plasmon resonance (SPR)
更新于2025-09-23 15:19:57
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Rapid detection of tryptamine by optosensor with molecularly imprinted polymers based on carbon dots-embedded covalent-organic frameworks
摘要： A rapid optosensing detection method for tryptamine (TRY) based on one-pot surface-imprinting synthesis methods has been developed. The optosensor consists of molecularly imprinted polymers (MIPs) based on carbon dots (CNs)-embedded covalent-organic frameworks (COFs). The principle of operation depends on adsorbents providing a large number of accessible recognition sites with high affinity and specificity, to achieve both a rapid uptake of and high capacity for TRY. After removing the template molecules, the desired molecular cavities were selected and fixed in a distinct manner to provide a defined chemical microenvironment for the reversible binding of the TRY target molecules. The optosensing system relied on the linear relationship between the fluorescence intensity of the TRY-imprinted polymers and the concentration of TRY in the range of 0.025–0.4 mg kg-1 with a detection limit of 7 μg kg-1. The system was used for efficiently detecting TRY in meat samples with recovery values from 91.42% to 119.80%.
关键词： covalent organic frameworks,meat,molecularly imprinted polymers,tryptamine,carbon nanodots
更新于2025-09-19 17:15:36
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Selective and sensitive determination of celastrol in traditional Chinese medicine based on molecularly imprinted polymers modified Mn-doped ZnS quantum dots optosensing materials
摘要： In this work, we proposed a facile strategy to prepare molecularly imprinted polymers (MIPs) modified Mn-doped ZnS quantum dots (QDs) as optosensing materials via sol-gel polymerization for specific recognition of celastrol (Cel) in traditional Chinese medicine (TCM). Firstly, L-Cysteine (L-Cys) modified Mn-doped ZnS QDs (L-Cys@Mn-ZnS) was used as imprinting substrate. The amino and carboxyl groups on the surface of Mn-ZnS QDs can provide more binding sites for imprinting polymerization. Then, the fluorescent MIPs was synthesized in the presence of L-Cys@Mn-ZnS QDs, template celastrol, 3-aminopropyl triethoxysilane (APTES) and ammonium hydroxide in the ethanol-water (9/1, v/v) solution. The morphology and structure of the products were characterized by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffractometer (XRD) and X-ray photoelectron spectroscopy (XPS). The resulting MIPs functionalized Mn-doped ZnS QDs (denoted as MIPs@L-Cys@Mn-ZnS QDs) had higher imprinting factor of 14.19 and significant selectivity. The MIPs@L-Cys@Mn-ZnS QDs as fluorescent probe exhibited sensitive response to Cel in the linear range from 0.1 μM to 3.5 μM and the limit of detection was estimated to be 35.2 nM. The probe was also applied for the detection of Cel in traditional Chinese medicine with recovery ranged from 88.0% to 105.0%. The results confirmed that MIPs@L-Cys@Mn-ZnS QDs could efficiently and specifically capture Cel from actual complex traditional Chinese medicine samples.
关键词： Celastol,Mn-doped ZnS quantum dots,fluorescent probe,traditional Chinese medicine,molecularly imprinted polymers
更新于2025-09-19 17:13:59
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SERS-based molecularly imprinted plasmonic sensor for highly sensitive PAH detection
摘要： A novel hybrid plasmonic platform based on the synergetic combination of a molecularly imprinted polymer (MIP) thin film with Au nanoparticles (NPs) assemblies, noted as Au@MIP, was developed for surface-enhanced Raman scattering (SERS) spectroscopy recognition of polycyclic aromatic hydrocarbons (PAHs). While the MIP trapped the PAH close to the Au surface, the plasmonic NPs enhanced the molecule Raman signal. The Au@MIP fabrication comprises a two-step procedure, first, the layer-by-layer deposition of Au NPs on glass and their further coating with a uniform MIP thin film. Profilometry analysis demonstrated that the thickness and homogeneity of the MIP film could be finely tailored by tuning different parameters such as prepolymerization time or spin-coating rate. Two different PAH molecules, pyrene or fluoranthene, were used as templates for the fabrication of pyrene- or fluoranthene-based Au@MIP substrates. The use of pyrene or fluoranthene, as a template molecule to fabricate the Au@MIP thin films, enabled its ultradetection in the nM regime with a 100-fold improvement compared with the non-imprinted plasmonic sensors (Au@NIPs). The SERS data analysis allows to estimate the binding constant of the template molecule to the MIP. The selectivity of both pyrene- and fluoranthene-based Au@MIPs was analyzed against three PAHs of different sizes. The results displayed the important role of the template molecule used for the Au@MIPs fabrication in the selectivity of the system. Finally, the practical applicability of pyrene-based Au@MIPs is shown by performing the detection of pyrene in two real samples: creek water and seawater. The design and optimization of this type of plasmonic platform pave the way for the detection of other relevant (bio)molecules in a broad range of fields such as environmental control, food safety or biomedicine.
关键词： Molecularly imprinted polymers,plasmonic sensors,polycyclic aromatic hydrocarbons,SERS,hybrid nanostructures,environmental analysis
更新于2025-09-19 17:13:59